| Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
| death D28 | 1.03 [0.96, 1.10] | | < 1 | | 0% | 11 studies (11/-) | 22.1 % | some concern | low | moderate | crucial | - |
| death or transfer to ICU | 1.09 [0.99, 1.20] | | < 1 | | 0% | 1 study (1/-) | 4.0 % | some concern | not evaluable | moderate | crucial | - |
| deaths | 0.99 [0.94, 1.04] | | < 1 | | 0% | 40 studies (40/-) | 67.4 % | some concern | critical | moderate | crucial | - |
| deaths (time to event analysis only) | 0.96 [0.87, 1.06] | | < 1 | | 43% | 10 studies (10/-) | 77.9 % | some concern | low | moderate | crucial | - |
| clinical deterioration | 1.06 [0.79, 1.42] | | < 1 | | 0% | 7 studies (7/-) | 34.6 % | some concern | not evaluable | moderate | important | - |
| clinical improvement | 1.24 [1.07, 1.44] | | > 1 | | 43% | 13 studies (13/-) | 99.8 % | some concern | low | moderate | important | - |
| clinical improvement (14-day) | 1.10 [0.93, 1.31] | | > 1 | | 43% | 16 studies (16/-) | 86.9 % | some concern | low | moderate | important | - |
| clinical improvement (28-day) | 1.24 [1.03, 1.50] | | > 1 | | 54% | 9 studies (9/-) | 98.8 % | some concern | not evaluable | moderate | important | - |
| clinical improvement (7-day) | 1.12 [0.95, 1.32] | | > 1 | | 36% | 11 studies (11/-) | 90.3 % | some concern | critical | moderate | important | - |
| clinical improvement (time to event analysis only) | 1.24 [1.14, 1.35] | | > 1 | | 0% | 10 studies (10/-) | 100.0 % | some concern | low | moderate | important | - |
| death or ventilation | 1.02 [0.95, 1.10] | | < 1 | | 20% | 8 studies (8/-) | 28.5 % | some concern | not evaluable | moderate | important | - |
| hospital discharge | 1.00 [0.93, 1.08] | | > 1 | | 30% | 8 studies (8/-) | 54.4 % | some concern | not evaluable | moderate | important | - |
| mechanical ventilation | 0.97 [0.77, 1.21] | | < 1 | | 27% | 14 studies (14/-) | 62.1 % | some concern | low | moderate | important | - |
| mechanical ventilation (time to event analysis only) | 0.06 [0.01, 0.83] | | < 1 | | 0% | 1 study (1/-) | 98.2 % | some concern | not evaluable | moderate | important | - |
| radiologic improvement (14-day) | 1.17 [0.42, 3.26] | | > 1 | | 16% | 3 studies (3/-) | 62.1 % | some concern | not evaluable | moderate | important | - |
| radiologic improvement (7-day) | 0.09 [0.01, 0.78] | | > 1 | | 0% | 2 studies (2/-) | 1.5 % | some concern | not evaluable | moderate | important | - |
| viral clearance | 1.43 [0.99, 2.05] | | > 1 | | 63% | 10 studies (10/-) | 97.2 % | some concern | low | moderate | important | - |
| viral clearance (time to event analysis only) | 1.32 [1.03, 1.69] | | > 1 | | 0% | 2 studies (2/-) | 98.6 % | some concern | not evaluable | moderate | important | - |
| viral clearance by day 14 | 0.99 [0.93, 1.06] | | > 1 | | 0% | 7 studies (7/-) | 40.5 % | some concern | not evaluable | moderate | important | - |
| viral clearance by day 7 | 1.01 [0.84, 1.21] | | > 1 | | 28% | 8 studies (8/-) | 53.7 % | some concern | not evaluable | moderate | important | - |
| ICU admission | 0.78 [0.47, 1.30] | | < 1 | | 0% | 7 studies (7/-) | 82.8 % | some concern | not evaluable | moderate | non important | - |
| off oxygenation | 0.98 [0.64, 1.51] | | > 1 | | 0% | 1 study (1/-) | 46.4 % | some concern | not evaluable | moderate | non important | - |
| recovery | 1.10 [0.94, 1.29] | | > 1 | | 60% | 4 studies (4/-) | 89.0 % | some concern | not evaluable | moderate | non important | - |
safety endpoints 00 |
| AE leading to drug discontinuation | 2.43 [0.79, 7.45] | | < 1 | | 0% | 1 study (1/-) | 6.0 % | low | not evaluable | high | important | - |
| cardiac arrest | 1.92 [0.35, 10.49] | | < 1 | | 0% | 1 study (1/-) | 22.7 % | some concern | not evaluable | moderate | important | - |
| related SAE (TRSAE) | 1.24 [0.50, 3.11] | | < 1 | | 0% | 1 study (1/-) | 32.0 % | some concern | not evaluable | moderate | important | - |
| serious adverse events | 0.84 [0.69, 1.03] | | < 1 | | 5% | 17 studies (17/-) | 95.5 % | some concern | low | moderate | important | - |
| adverse events | 1.68 [1.22, 2.33] | | < 1 | | 71% | 14 studies (14/-) | 0.1 % | some concern | low | moderate | non important | - |
| arrhythmia | 0.91 [0.72, 1.15] | | < 1 | | 0% | 3 studies (3/-) | 78.1 % | some concern | not evaluable | moderate | non important | - |
| deep vein thrombosis | 0.62 [0.23, 1.64] | | < 1 | | 0% | 2 studies (2/-) | 83.1 % | some concern | not evaluable | moderate | non important | - |
| elevated liver enzymes | 0.58 [0.34, 0.97] | | < 1 | | 6% | 2 studies (2/-) | |