Lopinavir/ritonavir plus hydroxychloroquine - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.58 [0.36, 0.93]< 10%1 study (1/-)98.9 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.58 [0.36, 0.93]< 10%1 study (1/-)98.9 %some concernnot evaluable moderatecrucial-
clinical improvement 0.63 [0.37, 1.06]> 10%1 study (1/-)4.2 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 0.63 [0.37, 1.06]> 10%1 study (1/-)4.2 %some concernnot evaluable moderateimportant-
hospital discharge 0.63 [0.43, 0.92]> 10%1 study (1/-)0.8 %some concernnot evaluable moderateimportant-

safety endpoints 00

serious adverse events 0.97 [0.22, 4.33]< 10%1 study (1/-)51.6 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.