anakinra - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.97 [0.46, 2.04]< 10%1 study (1/-)53.2 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.89 [0.42, 1.92]< 10%1 study (1/-)61.3 %some concernnot evaluable moderateimportant-
death or ventilation 0.97 [0.62, 1.52]< 10%1 study (1/-)55.3 %some concernnot evaluable moderateimportant-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.