patient subgroup...
age >= 60 yr autoimmune disease corticosteroids: no corticosteroids: yes critical disease invasive ventilation no oxygen needed non invasive oxygen severe disease subjects at risk
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
anti-inflammatoty and immuno-therapy - versus control - for COVID 19 hospitalized
method
abbreviations
Outcome
Relative effect 95%CI
LoD
Trt. better when
I2
k (RCT/OBS)
Bayesian probability
Overall ROB
Publication bias
Degree of certainty
Endpoint importance
Published MA
00 death D28 0.89 [0.81, 0.98]< 1 44% 24 studies (24/-) 98.8 % some concern critical moderate crucial - death or transfer to ICU 0.79 [0.50, 1.24]< 1 0% 2 studies (2/-) 84.9 % some concern not evaluable moderate crucial - deaths 0.90 [0.84, 0.95]< 1 34% 59 studies (59/-) 100.0 % some concern critical moderate crucial 1 deaths (time to event analysis only) 0.78 [0.61, 1.00]< 1 46% 8 studies (8/-) 97.6 % some concern not evaluable moderate crucial - clinical deterioration 0.68 [0.55, 0.85]< 1 46% 17 studies (17/-) 100.0 % some concern low moderate important - clinical improvement 1.16 [1.05, 1.28]> 1 27% 19 studies (19/-) 99.8 % some concern low moderate important - clinical improvement (14-day) 1.51 [1.01, 2.26]> 1 25% 4 studies (4/-) 97.7 % some concern not evaluable moderate important - clinical improvement (28-day) 1.29 [0.92, 1.81]> 1 56% 5 studies (5/-) 93.3 % some concern serious moderate important - clinical improvement (7-day) 0.86 [0.58, 1.28]> 1 0% 2 studies (2/-) 23.1 % some concern not evaluable moderate important - clinical improvement (time to event analysis only) 1.15 [1.05, 1.26]> 1 4% 12 studies (12/-) 99.8 % some concern low moderate important - death or ventilation 0.90 [0.84, 0.97]< 1 56% 17 studies (17/-) 99.8 % some concern low moderate important - hospital discharge 1.08 [1.01, 1.16]> 1 41% 10 studies (10/-) 98.6 % some concern low moderate important - hospitalization 1.00 [0.14, 7.34]< 1 0% 1 study (1/-) 50.0 % some concern not evaluable moderate important - mechanical ventilation 0.84 [0.74, 0.96]< 1 14% 21 studies (21/-) 99.4 % some concern low moderate important 1 radiologic improvement (14-day) 3.53 [1.19, 10.46]> 1 0% 2 studies (2/-) 98.9 % some concern not evaluable moderate important - viral clearance 3.00 [0.87, 10.35]> 1 92% 4 studies (4/-) 95.9 % some concern not evaluable moderate important - viral clearance (time to event analysis only) 1.18 [0.54, 2.54]> 1 83% 2 studies (2/-) 66.0 % some concern not evaluable moderate important - viral clearance by day 14 6.64 [0.42, 104.56]> 1 95% 3 studies (3/-) 90.9 % some concern not evaluable moderate important - viral clearance by day 7 1.10 [0.48, 2.49]> 1 42% 2 studies (2/-) 58.7 % some concern not evaluable moderate important - ICU admission 0.64 [0.46, 0.90]< 1 35% 12 studies (12/-) 99.5 % some concern critical moderate non important - recovery 1.25 [0.72, 2.19]> 1 44% 3 studies (3/-) 78.5 % some concern not evaluable moderate non important - 00 composite safety outcome 1.56 [0.78, 3.11]< 1 0% 1 study (1/-) 10.3 % low not evaluable high important - serious adverse events 1.11 [0.97, 1.26]< 1 5% 20 studies (20/-) 6.7 % some concern low moderate important - superinfection 0.70 [0.46, 1.07]< 1 53% 4 studies (4/-) 95.0 % some concern not evaluable moderate important - adverse events 1.25 [1.01, 1.55]< 1 21% 13 studies (13/-) 2.1 % some concern critical moderate non important -
LoD: level of statistical demonstration:
