pegylated interferon-α2b - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 2.45 [0.21, 28.37]< 10%2 studies (2/-)23.8 %some concernnot evaluable moderatecrucial-
deaths 2.45 [0.21, 28.37]< 10%2 studies (2/-)23.8 %some concernnot evaluable moderatecrucial-
clinical improvement 0.68 [0.21, 2.20]> 10%1 study (1/-)25.9 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 2.03 [0.17, 24.32]> 175%2 studies (2/-)71.0 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 1.91 [1.03, 3.53]> 10%1 study (1/-)98.0 %some concernnot evaluable moderateimportant-
viral clearance 2.69 [1.48, 4.87]> 10%2 studies (2/-)99.9 %some concernnot evaluable moderateimportant-
viral clearance by day 14 0.18 [0.00, 435.69]> 198%2 studies (2/-)34.4 %some concernnot evaluable moderateimportant-
viral clearance by day 7 2.69 [1.48, 4.87]> 10%2 studies (2/-)99.9 %some concernnot evaluable moderateimportant-

safety endpoints 00

serious adverse events 0.95 [0.02, 50.33]< 10%1 study (1/-)51.0 %some concernnot evaluable moderateimportant-
adverse events 1.68 [0.47, 5.97]< 10%1 study (1/-)21.1 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.