colchicine - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.00 [0.94, 1.06]< 10%5 studies (5/-)51.9 %some concernserious moderatecrucial-
deaths 1.00 [0.94, 1.06]< 10%7 studies (7/-)53.3 %some concernserious moderatecrucial-
deaths (time to event analysis only) 0.88 [0.70, 1.11]< 10%1 study (1/-)85.7 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.27 [0.08, 0.90]< 10%2 studies (2/-)98.3 %some concernnot evaluable moderateimportant-
death or ventilation 0.94 [0.78, 1.15]< 170%2 studies (2/-)71.9 %some concernnot evaluable moderateimportant-
hospital discharge 0.98 [0.94, 1.03]> 10%1 study (1/-)19.3 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.93 [0.73, 1.18]< 149%4 studies (4/-)73.0 %some concernnot evaluable moderateimportant-
ICU admission 0.92 [0.54, 1.58]< 10%2 studies (2/-)61.6 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 0.24 [0.01, 5.41]< 10%1 study (1/-)81.3 %some concernnot evaluable moderateimportant-
adverse events 1.72 [0.73, 4.08]< 10%1 study (1/-)10.9 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.