losartan - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.29 [0.51, 3.26]< 10%1 study (1/-)29.5 %NAnot evaluable crucial-
deaths 0.68 [0.11, 4.16]< 10%1 study (1/-)66.1 %NAnot evaluable crucial-
hospital discharge 0.64 [0.37, 1.11]> 10%1 study (1/-)5.6 %NAnot evaluable important-
hospitalization 1.63 [0.94, 2.85]< 10%1 study (1/-)4.2 %NAnot evaluable important-
mechanical ventilation 1.34 [0.66, 2.73]< 10%1 study (1/-)20.6 %NAnot evaluable important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.