hydroxychloroquine - for COVID 19 hospitalized method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 1.10 [0.99, 1.22]< 10%13 studies (13 / -)4.5 %some concernlow moderatecrucial-
deaths (time to event analysis only) 1.10 [0.99, 1.23]< 10%2 studies (2 / -)3.9 %some concernnot evaluable moderatecrucial-
clinical improvement 1.91 [0.80, 4.53]> 148%2 studies (2 / -)92.8 %highnot evaluable lowimportant-
clinical improvement (14-day) 1.14 [0.56, 2.31]> 115%2 studies (2 / -)64.3 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only)no RCT reported results for this endpoint, but 4 observational studies are available. Clear RCT filter to include observational studies
clinical worsening 0.55 [0.09, 3.27]< 147%2 studies (2 / -)74.5 %highnot evaluable lowimportant-
death or ventilation 1.14 [1.03, 1.25]< 10%2 studies (2 / -)0.5 %some concernnot evaluable moderateimportant-
PCR-negative conversion 0.46 [0.04, 5.75]> 10%1 study (1 / -)27.7 %some concernnot evaluable moderateimportant-
PCR-negative conversion (14-day) 1.09 [0.95, 1.26]> 10%2 studies (2 / -)88.8 %some concernnot evaluable moderateimportant-
PCR-negative conversion (7-day) 1.12 [0.58, 2.19]> 10%2 studies (2 / -)63.2 %some concernnot evaluable moderateimportant-
radiologic improvement (14-day) 1.33 [0.94, 1.88]> 10%1 study (1 / -)94.7 %some concernnot evaluable moderateimportant-
radiologic improvement (7-day) 3.43 [1.10, 10.70]> 10%1 study (1 / -)98.3 %highnot evaluable lowimportant-
radiologic progression 0.57 [0.13, 2.50]< 10%1 study (1 / -)77.1 %some concernnot evaluable moderateimportant-
ventilationno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ventilation (time to event analysis only)no RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ICU admission 0.83 [0.35, 1.95]< 10%1 study (1 / -)66.8 %some concernnot evaluable moderatenon important-

-- safety endpoints 00

cardiac arrestno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
abnormal ECG findingsno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
arrhythmiano RCT reported results for this endpoint, but 4 observational studies are available. Clear RCT filter to include observational studies
diarrhea and abnormal liver function 1.45 [0.26, 8.01]< 10%1 study (1 / -)33.4 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 4 pathologies: 95,94,90,91 95, 90,94, 90, 91