Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
chloroquine and derivatives40 1.20 [0.85; 1.70], 4 RCTs, I2=34%
inconclusive result
1.05 [0.80; 1.37], 5 RCTs, I2=0%
inconclusive result
1.08 [0.98; 1.20], 23 RCTs, I2=0%
inconclusive result
0.83 [0.57; 1.21], 2 RCTs, I2=0%
inconclusive result
hydroxychloroquine plus macrolides8- 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
0.72 [0.22; 2.41], 2 RCTs, I2=0%
inconclusive result
-
Renin-angiotensin-system-acting agents7- OBS 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
0.97 [0.38; 2.50], 1 RCT, I2=0%
inconclusive result
-
remdesivir6 1.32 [1.16; 1.50], 4 RCTs, I2=0% demonstrated
moderate degree of certainty
- 0.91 [0.79; 1.05], 5 RCTs, I2=0%
inconclusive result
-
lopinavir/ritonavir5 1.72 [0.98; 3.01], 3 RCTs, I2=64%
inconclusive result
3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
1.01 [0.91; 1.13], 6 RCTs, I2=0%
inconclusive result
3.24 [1.15; 9.10], 2 RCTs, I2=24% demonstrated
moderate degree of certainty
ivermectin4 OBS 0.90 [0.04; 20.92], 1 study, I2=0%
inconclusive result
0.40 [0.10; 1.63], 1 RCT, I2=0%
inconclusive result
0.19 [0.03; 1.18], 2 RCTs, I2=69%
inconclusive result
OBS 0.52 [0.10; 2.58], 1 study, I2=0%
inconclusive result
umifenovir (arbidol)3 OBS 0.75 [0.47; 1.20], 1 study, I2=0%
inconclusive result
0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
1.00 [0.18; 5.59], 2 RCTs, I2=0%
inconclusive result
2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
azithromycin2- 1.26 [0.93; 1.70], 2 RCTs, I2=0%
inconclusive result
2.00 [0.36; 11.17], 2 RCTs, I2=64%
inconclusive result
-
doxycycline1- 0.40 [0.10; 1.63], 1 RCT, I2=0%
inconclusive result
0.48 [0.11; 1.99], 1 RCT, I2=0%
inconclusive result
-
favipiravir 1----
lopinavir/ritonavir, ribavirin and interferon beta-1b1 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
- 0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
4.37 [1.86; 10.25], 1 RCT, I2=0% demonstrated
moderate degree of certainty
oseltamivir1 OBS 0.76 [0.42; 1.37], 1 study, I2=0%
inconclusive result
- 0.51 [0.04; 6.12], 1 RCT, I2=0%
inconclusive result
OBS 1.03 [0.57; 1.87], 1 study, I2=0%
inconclusive result
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
fluvoxamine0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
meplazumab0----
nitazoxanide0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----