Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE).
method
Treament |
Trials |
|
|
clinical deterioration | clinical improvement | deaths | PCR-negative conversion |
chloroquine and derivatives | 6 | - | 1.36 [0.87; 2.11], 1 RCT, I2=0% inconclusive result | 1.06 [0.21; 5.31], 5 RCTs, I2=0% inconclusive result | 0.93 [0.62; 1.40], 2 RCTs, I2=0% inconclusive result | |
ivermectin | 4 | - | - | - | 0.92 [0.77; 1.09], 2 RCTs, I2=0% inconclusive result | |
azithromycin | 1 | - | - | - | OBS 715.00 [12.94; 39513.71], 1 study, I2=0% unassessable degree of certainty | |
doxycycline | 1 | - | - | - | - | |
fluvoxamine | 1 | 0.07 [0.00; 1.26], 1 RCT, I2=0% demonstrated inconclusive result | - | - | - | |
hydroxychloroquine plus macrolides | 1 | - | - | - | 0.64 [0.42; 0.98], 2 RCTs, I2=0% statistically significant harm | |
ASC09/ritonavir | 0 | - | - | - | - | |
azvudine | 0 | - | - | - | - | |
baloxavir marboxil | 0 | - | - | - | - | |
carrimycin | 0 | - | - | - | - | |
danoprevir / ritonavir | 0 | - | - | - | - | |
darunavir cobicistat | 0 | - | - | - | - | |
darunavir/cobicistat plus chloroquine | 0 | - | - | - | - | |
favipiravir | 0 | - | - | - | - | |
leronlimab | 0 | - | - | - | - | |
lopinavir / ritonavir plus ribavirin | 0 | - | - | - | - | |
lopinavir/ritonavir | 0 | - | - | - | - | |
lopinavir/ritonavir plus chloroquine | 0 | - | - | - | - | |
lopinavir/ritonavir plus interferon ß-1a | 0 | - | - | - | - | |
lopinavir/ritonavir, ribavirin and interferon beta-1b | 0 | - | - | - | - | |
meplazumab | 0 | - | - | - | - | |
nitazoxanide | 0 | - | - | - | - | |
oseltamivir | 0 | - | - | - | - | |
oseltamivir plus chloroquin | 0 | - | - | - | - | |
remdesivir | 0 | - | - | - | - | |
Renin-angiotensin-system-acting agents | 0 | - | - | - | - | |
ribavirin | 0 | - | - | - | - | |
ritonavir | 0 | - | - | - | - | |
sofosbuvir and daclatasvir | 0 | - | - | - | - | |
tenofovir/emtricitabine | 0 | - | - | - | - | |
tenofovir/emtricitabine plus hydroxychloroquine | 0 | - | - | - | - | |
tranexamic acid | 0 | - | - | - | - | |
triazavirin | 0 | - | - | - | - | |
umifenovir (arbidol) | 0 | - | - | - | - | |