Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
ivermectin11 0.94 [0.77; 1.15], 3 RCTs, I2=0%
inconclusive result
1.07 [0.98; 1.17], 2 RCTs, I2=0%
inconclusive result
0.93 [0.54; 1.59], 4 RCTs, I2=0%
inconclusive result
0.92 [0.77; 1.09], 2 RCTs, I2=0%
inconclusive result
chloroquine and derivatives8 0.51 [0.07; 3.68], 1 RCT, I2=0%
inconclusive result
1.36 [0.87; 2.11], 1 RCT, I2=0%
inconclusive result
1.32 [0.44; 3.93], 5 RCTs, I2=0%
inconclusive result
0.93 [0.62; 1.40], 2 RCTs, I2=0%
inconclusive result
azithromycin4- 1.08 [0.95; 1.23], 1 RCT, I2=0%
inconclusive result
1.65 [0.03; 83.12], 1 RCT, I2=0%
inconclusive result
OBS 715.00 [12.94; 39513.71], 1 study, I2=0%
unassessable degree of certainty
fluvoxamine4 0.72 [0.45; 1.16], 3 RCTs, I2=61% demonstrated
inconclusive result
- 0.80 [0.43; 1.50], 1 RCT, I2=0%
inconclusive result
0.67 [0.42; 1.06], 1 RCT, I2=0%
inconclusive result
hydroxychloroquine plus macrolides2--- 0.91 [0.54; 1.51], 2 RCTs, I2=0%
inconclusive result
molnupiravir2-- 0.10 [0.01; 0.92], 2 RCTs, I2=0%
high degree of certainty
14.50 [1.70; 123.69], 1 RCT, I2=0%
unassessable degree of certainty
lopinavir/ritonavir1-- 0.26 [0.01; 5.88], 1 RCT, I2=0%
inconclusive result
0.92 [0.82; 1.03], 1 RCT, I2=0%
inconclusive result
nirmatrelvir / ritonavir (Paxlovid)1-- 0.04 [0.00; 0.70], 1 RCT, I2=0%
unassessable degree of certainty
-
nitazoxanide1----
remdesivir1-- 1.01 [0.02; 51.30], 1 RCT, I2=0%
inconclusive result
-
sofosbuvir and daclatasvir1----
zinc1----
Amantadine0----
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
doxycycline0----
Emtricitabine/tenofovir plus colchicine plus rosuvastatin0----
Ensitrelvir (XOCOVA)0----
favipiravir 0----
favipiravir plus interferon0----
Interferon plus lopinavir/ritonavir0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
Lopinavir/ritonavir plus hydroxychloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
lopinavir/ritonavir, ribavirin and interferon beta-1b0----
niclosamide0----
opaganib0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
sofosbuvir0----
sofosbuvir and ledipasvir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
tranilast0----
triazavirin0----
umifenovir (arbidol)0----