Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE).
method
| Treament |
Trials |
|
|
| clinical deterioration | clinical improvement | deaths | PCR-negative conversion |
| chloroquine and derivatives | 6 | - | 1.36 [0.87; 2.11], 1 RCT, I2=0%
inconclusive result | 1.06 [0.21; 5.31], 5 RCTs, I2=0%
inconclusive result | 0.93 [0.62; 1.40], 2 RCTs, I2=0%
inconclusive result | |
| ivermectin | 4 | - | - | - | 0.92 [0.77; 1.09], 2 RCTs, I2=0%
inconclusive result | |
| azithromycin | 1 | - | - | - | OBS 715.00 [12.94; 39513.71], 1 study, I2=0%
unassessable degree of certainty | |
| doxycycline | 1 | - | - | - | - | |
| fluvoxamine | 1 | 0.07 [0.00; 1.26], 1 RCT, I2=0% demonstrated
inconclusive result | - | - | - | |
| hydroxychloroquine plus macrolides | 1 | - | - | - | 0.64 [0.42; 0.98], 2 RCTs, I2=0%
statistically significant harm | |
| ASC09/ritonavir | 0 | - | - | - | - | |
| azvudine | 0 | - | - | - | - | |
| baloxavir marboxil | 0 | - | - | - | - | |
| carrimycin | 0 | - | - | - | - | |
| danoprevir / ritonavir | 0 | - | - | - | - | |
| darunavir cobicistat | 0 | - | - | - | - | |
| darunavir/cobicistat plus chloroquine | 0 | - | - | - | - | |
| favipiravir | 0 | - | - | - | - | |
| leronlimab | 0 | - | - | - | - | |
| lopinavir / ritonavir plus ribavirin | 0 | - | - | - | - | |
| lopinavir/ritonavir | 0 | - | - | - | - | |
| lopinavir/ritonavir plus chloroquine | 0 | - | - | - | - | |
| lopinavir/ritonavir plus interferon ß-1a | 0 | - | - | - | - | |
| lopinavir/ritonavir, ribavirin and interferon beta-1b | 0 | - | - | - | - | |
| meplazumab | 0 | - | - | - | - | |
| nitazoxanide | 0 | - | - | - | - | |
| oseltamivir | 0 | - | - | - | - | |
| oseltamivir plus chloroquin | 0 | - | - | - | - | |
| remdesivir | 0 | - | - | - | - | |
| Renin-angiotensin-system-acting agents | 0 | - | - | - | - | |
| ribavirin | 0 | - | - | - | - | |
| ritonavir | 0 | - | - | - | - | |
| sofosbuvir and daclatasvir | 0 | - | - | - | - | |
| tenofovir/emtricitabine | 0 | - | - | - | - | |
| tenofovir/emtricitabine plus hydroxychloroquine | 0 | - | - | - | - | |
| tranexamic acid | 0 | - | - | - | - | |
| triazavirin | 0 | - | - | - | - | |
| umifenovir (arbidol) | 0 | - | - | - | - | |
