Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsPCR-negative conversion
chloroquine and derivatives47 1.15 [0.92; 1.43], 6 RCTs, I2=2%
inconclusive result
1.21 [0.94; 1.57], 5 RCTs, I2=20%
inconclusive result
1.08 [0.98; 1.19], 30 RCTs, I2=0%
inconclusive result
0.88 [0.67; 1.16], 4 RCTs, I2=0%
inconclusive result
ivermectin23 0.45 [0.26; 0.80], 3 RCTs, I2=0%
low degree of certainty
1.67 [1.05; 2.66], 3 RCTs, I2=0%
low degree of certainty
0.24 [0.10; 0.55], 5 RCTs, I2=36%
low degree of certainty
0.92 [0.77; 1.09], 2 RCTs, I2=0%
inconclusive result
favipiravir 15- 1.46 [1.08; 1.96], 6 RCTs, I2=19%
moderate degree of certainty
0.78 [0.28; 2.22], 5 RCTs, I2=0%
inconclusive result
1.64 [1.10; 2.44], 7 RCTs, I2=56%
low degree of certainty
hydroxychloroquine plus macrolides9 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
- 0.72 [0.22; 2.41], 2 RCTs, I2=0%
inconclusive result
0.64 [0.42; 0.98], 2 RCTs, I2=0%
statistically significant harm
Renin-angiotensin-system-acting agents9 OBS 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
- 0.92 [0.47; 1.77], 2 RCTs, I2=0%
inconclusive result
-
azithromycin8 1.26 [0.93; 1.70], 2 RCTs, I2=0%
inconclusive result
- 1.03 [0.87; 1.21], 4 RCTs, I2=13%
inconclusive result
OBS 715.00 [12.94; 39513.71], 1 study, I2=0%
unassessable degree of certainty
lopinavir/ritonavir6 3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
1.72 [0.98; 3.01], 3 RCTs, I2=64%
inconclusive result
1.01 [0.91; 1.13], 7 RCTs, I2=0%
inconclusive result
3.24 [1.15; 9.10], 2 RCTs, I2=24% demonstrated
moderate degree of certainty
remdesivir6- 1.24 [1.13; 1.36], 5 RCTs, I2=0% demonstrated
moderate degree of certainty
0.89 [0.78; 1.02], 6 RCTs, I2=0%
inconclusive result
-
doxycycline5 0.44 [0.24; 0.78], 2 RCTs, I2=0%
low degree of certainty
1.89 [1.06; 3.38], 1 RCT, I2=0%
low degree of certainty
0.39 [0.11; 1.42], 2 RCTs, I2=0%
inconclusive result
-
umifenovir (arbidol)4 0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
1.00 [0.18; 5.59], 2 RCTs, I2=0%
inconclusive result
2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
azvudine1----
baloxavir marboxil1----
fluvoxamine1 0.07 [0.00; 1.26], 1 RCT, I2=0% demonstrated
inconclusive result
---
lopinavir/ritonavir, ribavirin and interferon beta-1b1- 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
4.37 [1.86; 10.25], 1 RCT, I2=0% demonstrated
moderate degree of certainty
oseltamivir1- OBS 0.76 [0.42; 1.37], 1 study, I2=0%
inconclusive result
0.51 [0.04; 6.12], 1 RCT, I2=0%
inconclusive result
OBS 1.03 [0.57; 1.87], 1 study, I2=0%
inconclusive result
ASC09/ritonavir0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
meplazumab0----
nitazoxanide0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
sofosbuvir and daclatasvir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----