Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
Immunosuppressants drugs24 1.17 [1.00; 1.38], 5 RCTs, I2=0%
low degree of certainty
0.78 [0.53; 1.14], 4 RCTs, I2=36%
inconclusive result
1.08 [0.77; 1.52], 6 RCTs, I2=0%
inconclusive result
-
corticosteroids14 1.16 [0.84; 1.60], 2 RCTs, I2=0%
inconclusive result
0.66 [0.43; 1.02], 1 RCT, I2=0%
inconclusive result
0.81 [0.65; 0.99], 7 RCTs, I2=59% demonstrated
low degree of certainty
-
Immunostimulants drugs11 1.11 [0.75; 1.62], 2 RCTs, I2=10%
inconclusive result
- 0.74 [0.43; 1.25], 4 RCTs, I2=17%
inconclusive result
-
anti-inflammatory therapies1-- OBS 0.41 [0.19; 0.89], 1 study, I2=0%
very low degree of certainty
-
acalabrutinib0----
anticorps0----
Apilimod0----
imatinib0----
leflunomide0----
pirfenidone0----
Polyinosinic-Polycytidylic Acid0----
sargramostim0----
thymosin0----