Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsPCR-negative conversion
Immunostimulants drugs34 0.52 [0.28; 0.95], 3 RCTs, I2=6% demonstrated
low degree of certainty
1.06 [0.78; 1.45], 5 RCTs, I2=45%
inconclusive result
1.06 [0.98; 1.14], 15 RCTs, I2=0%
inconclusive result
6.33 [1.54; 26.00], 1 RCT, I2=0%
unassessable degree of certainty
Immunosuppressants drugs27 0.78 [0.53; 1.14], 4 RCTs, I2=36%
inconclusive result
1.28 [1.10; 1.49], 9 RCTs, I2=42% demonstrated
low degree of certainty
0.81 [0.66; 0.98], 10 RCTs, I2=0%
low degree of certainty
-
corticosteroids15 0.81 [0.46; 1.42], 3 RCTs, I2=81%
inconclusive result
1.16 [0.84; 1.60], 2 RCTs, I2=0%
inconclusive result
0.87 [0.72; 1.05], 7 RCTs, I2=59% demonstrated
inconclusive result
-
anti-inflammatory therapies8 OBS 0.43 [0.02; 8.34], 2 studies, I2=88%
inconclusive result
OBS 12.75 [1.61; 100.79], 1 study, I2=0%
unassessable degree of certainty
OBS 0.85 [0.65; 1.10], 6 studies, I2=19%
inconclusive result
-
acalabrutinib2----
A EFFACER anticorps0----
Apilimod0----
imatinib0----
leflunomide0----
pirfenidone0----
Polyinosinic-Polycytidylic Acid0----
sargramostim0----
thymosin0----