Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
Immunostimulants drugs75 0.86 [0.74; 1.01], 12 RCTs, I2=0% demonstrated
inconclusive result
1.12 [1.00; 1.25], 19 RCTs, I2=38% demonstrated
inconclusive result
0.90 [0.82; 0.98], 62 RCTs, I2=18% demonstrated
low degree of certainty
3.51 [1.38; 8.94], 7 RCTs, I2=87%
low degree of certainty
Immunosuppressants drugs69 0.70 [0.51; 0.96], 11 RCTs, I2=59% demonstrated
moderate degree of certainty
1.25 [1.13; 1.38], 14 RCTs, I2=15% demonstrated
low degree of certainty
0.77 [0.69; 0.86], 44 RCTs, I2=22% demonstrated
safety concern
inconclusive result
-
anti-inflammatory therapies26 0.18 [0.05; 0.57], 4 RCTs, I2=14%
moderate degree of certainty
10.27 [1.17; 90.18], 1 RCT, I2=0%
moderate degree of certainty
0.99 [0.94; 1.05], 12 RCTs, I2=0%
inconclusive result
1.71 [0.80; 3.64], 1 RCT, I2=0%
inconclusive result
corticosteroids22 0.67 [0.44; 1.03], 2 RCTs, I2=0%
inconclusive result
1.44 [0.89; 2.33], 4 RCTs, I2=65%
inconclusive result
0.85 [0.73; 0.99], 15 RCTs, I2=64% demonstrated
low degree of certainty
1.78 [1.06; 3.00], 1 RCT, I2=0%
moderate degree of certainty
Kinase inhibitors3----
leflunomide1 1.00 [0.02; 52.54], 1 RCT, I2=0%
inconclusive result
- 1.00 [0.02; 52.54], 1 RCT, I2=0%
inconclusive result
-
Apilimod0----
inhaled corticosteroids0----
meplazumab0----
pirfenidone0----
Polyinosinic-Polycytidylic Acid0----
sargramostim0----
statins0----
thymosin0----