Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
bromhexine3 0.48 [0.01; 27.44], 1 RCT, I2=0%
inconclusive result
- 0.09 [0.00; 1.68], 1 RCT, I2=0%
inconclusive result
-
proton pump inhibitors (PPI)3 OBS 2.71 [1.17; 6.30], 1 study, I2=0%
statistically significant harm
- OBS 2.76 [1.51; 5.06], 2 studies, I2=0%
statistically significant harm
-
stem cells3 0.27 [0.01; 5.58], 1 RCT, I2=0%
inconclusive result
10.27 [1.17; 90.18], 1 RCT, I2=0%
moderate degree of certainty
0.20 [0.04; 0.98], 3 RCTs, I2=0%
moderate degree of certainty
-
TD-09033- 2.74 [0.40; 18.83], 2 RCTs, I2=0%
inconclusive result
0.27 [0.03; 2.26], 2 RCTs, I2=0%
inconclusive result
-
vitamin C3 0.52 [0.21; 1.30], 3 RCTs, I2=0%
inconclusive result
1.67 [0.84; 3.33], 1 RCT, I2=0%
inconclusive result
0.57 [0.29; 1.11], 4 RCTs, I2=0%
inconclusive result
-
alpha lipoic acid1-- 0.17 [0.02; 1.44], 1 RCT, I2=0%
inconclusive result
-
camostat mesilate1- 1.14 [0.83; 1.57], 1 RCT, I2=0%
inconclusive result
0.70 [0.20; 2.49], 1 RCT, I2=0%
inconclusive result
-
dapagliflozin1----
povidone-iodine1----
progesterone1- 1.31 [1.00; 1.71], 1 RCT, I2=0%
moderate degree of certainty
--
thalidomide 1----
zinc1-- 0.77 [0.11; 5.34], 1 RCT, I2=0%
inconclusive result
-
2-deoxy-D-glucose (2-DG)0----
acetylcysteine0----
anti GM-CSF0----
anti-CK20----
aviptadil0----
bevacizumab0----
bismuth0----
BLD-2660 (calpain inhibitor)0----
calcium channel blocker0----
continuous positive airway pressure (CPAP)0----
cytokine adsorption0----
diammonium glycyrrhizinate0----
dipyridamol0----
dornase alfa0----
DPP-4 inhibitor0----
expectorants and mucolytics0----
kinin-kallikrein inhibitors0----
lenzilumab0----
levamisole0----
melatonin0----
metformin0----
mouthrise and gargling agents0----
N-Acetylcysteine0----
nasal spray0----
natural killer (NK) cells0----
niclosamide0----
nicotin0----
nigella sativa oil0----
nitric oxide (gas Inhalation or releasing solution)0----
omega-3 Polyunsaturated Fatty Acids0----
ozonated autohemotherapy0----
pamrevlumab0----
plasma exchange0----
prostacyclin0----
PUL-042 inhalation solution0----
radiotherapy0----
selinexor0----
statins0----
tradipitant0----
tranilast0----
triiodothyronine (T3)0----