Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
ivermectin15 0.47 [0.27; 0.83], 3 RCTs, I2=0%
low degree of certainty
1.72 [1.02; 2.88], 2 RCTs, I2=0%
low degree of certainty
0.43 [0.13; 1.39], 4 RCTs, I2=0%
inconclusive result
0.92 [0.77; 1.09], 1 RCT, I2=0%
inconclusive result
chloroquine and derivatives6 0.98 [0.64; 1.52], 3 RCTs, I2=26%
inconclusive result
1.01 [0.59; 1.74], 1 RCT, I2=0%
inconclusive result
1.13 [0.54; 2.36], 7 RCTs, I2=0%
inconclusive result
0.83 [0.57; 1.21], 2 RCTs, I2=0%
inconclusive result
favipiravir 6- 1.66 [1.28; 2.15], 4 RCTs, I2=0%
moderate degree of certainty
0.57 [0.12; 2.77], 4 RCTs, I2=0%
inconclusive result
1.83 [1.12; 2.99], 5 RCTs, I2=67%
moderate degree of certainty
azithromycin3- 0.82 [0.47; 1.43], 1 RCT, I2=0%
inconclusive result
0.43 [0.13; 1.44], 1 RCT, I2=0%
inconclusive result
OBS 715.00 [12.94; 39513.71], 1 study, I2=0%
unassessable degree of certainty
remdesivir3- 1.12 [0.72; 1.75], 3 RCTs, I2=79% demonstrated
inconclusive result
0.70 [0.39; 1.26], 3 RCTs, I2=0%
inconclusive result
-
nitazoxanide2 1.02 [0.29; 3.58], 1 RCT, I2=0%
inconclusive result
0.81 [0.52; 1.27], 1 RCT, I2=0%
inconclusive result
1.02 [0.02; 51.70], 1 RCT, I2=0%
inconclusive result
-
umifenovir (arbidol)2 0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
-- 2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
azvudine1-- 1.00 [0.02; 55.80], 1 RCT, I2=0%
inconclusive result
28.50 [1.27; 640.66], 1 RCT, I2=0%
moderate degree of certainty
doxycycline1 0.44 [0.23; 0.84], 1 RCT, I2=0%
low degree of certainty
1.89 [1.06; 3.38], 1 RCT, I2=0%
low degree of certainty
0.16 [0.01; 3.25], 1 RCT, I2=0%
inconclusive result
-
favipiravir plus interferon1-- 0.83 [0.23; 2.96], 1 RCT, I2=0%
inconclusive result
-
hydroxychloroquine plus macrolides1 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
- 0.62 [0.24; 1.60], 2 RCTs, I2=0%
inconclusive result
-
lopinavir/ritonavir1 3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
3.24 [1.15; 9.10], 2 RCTs, I2=24% demonstrated
moderate degree of certainty
lopinavir/ritonavir, ribavirin and interferon beta-1b1- 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
4.37 [1.86; 10.25], 1 RCT, I2=0% demonstrated
moderate degree of certainty
Renin-angiotensin-system-acting agents1-- 0.97 [0.38; 2.50], 1 RCT, I2=0%
inconclusive result
-
sofosbuvir and ledipasvir1----
ASC09/ritonavir0----
azithromycin plus hydroxychloroquine0----
baloxavir marboxil0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
fluvoxamine0----
Interferon plus lopinavir/ritonavir0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
molnupiravir0----
opaganib0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
sofosbuvir0----
sofosbuvir and daclatasvir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----