Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
chloroquine and derivatives6 1.68 [0.52; 5.44], 2 RCTs, I2=72%
inconclusive result
0.98 [0.64; 1.52], 3 RCTs, I2=26%
inconclusive result
1.30 [0.49; 3.46], 5 RCTs, I2=0%
inconclusive result
0.83 [0.57; 1.21], 2 RCTs, I2=0%
inconclusive result
remdesevir3 1.38 [0.98; 1.95], 2 RCTs, I2=30% demonstrated
inconclusive result
- 0.65 [0.21; 2.01], 2 RCTs, I2=0%
inconclusive result
-
hydroxychloroquine plus macrolides1- 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
0.64 [0.18; 2.24], 1 RCT, I2=0%
inconclusive result
-
ivermectin1 OBS 0.90 [0.04; 20.92], 1 study, I2=0%
inconclusive result
- OBS 1.11 [0.05; 25.91], 1 study, I2=0%
inconclusive result
-
lopinavir/ritonavir1 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
3.24 [1.15; 9.10], 2 RCTs, I2=24% demonstrated
moderate degree of certainty
lopinavir/ritonavir, ribavirin and interferon beta-1b1 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
- 0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
4.37 [1.86; 10.25], 1 RCT, I2=0% demonstrated
moderate degree of certainty
umifenovir (arbidol)1- 0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
- 2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
ASC09/ritonavir0----
azithromycin0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
doxycycline0----
favipiravir 0----
fluvoxamine0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
meplazumab0----
nitazoxanide0----
oseltamivir0----
oseltamivir plus chloroquin0----
Renin-angiotensin-system-acting agents0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----