fluvoxamine - versus control - for COVID 19 outpatients pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.69 [0.37, 1.30]< 10%1 study (1/-)87.6 %NAnot evaluable crucial-
deaths 0.80 [0.43, 1.50]< 10%1 study (1/-)75.7 %NAnot evaluable crucial-
deaths (time to event analysis only) 0.80 [0.43, 1.50]< 10%1 study (1/-)75.7 %NAnot evaluable crucial-
hospitalization or death 0.78 [0.58, 1.03]< 10%2 studies (2/-)96.0 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.72 [0.45, 1.16]< 161%3 studies (3/-)91.1 %some concernnot evaluable moderateimportant-
hospitalization 0.77 [0.58, 1.02]< 10%3 studies (3/-)96.5 %some concernnot evaluable moderateimportant-
viral clearance 0.67 [0.42, 1.06]> 10%1 study (1/-)4.5 %NAnot evaluable important-
viral clearance by day 7 0.67 [0.42, 1.06]> 10%1 study (1/-)4.5 %NAnot evaluable important-
emergency room observation for > 6 hours or hospitalization 0.64 [0.47, 0.87]< 10%1 study (1/-)99.8 %NAnot evaluable non important-
recovery 0.96 [0.86, 1.07]> 10%1 study (1/-)23.2 %NAnot evaluable non important-

safety endpoints 00

AE leading to drug discontinuation 1.38 [0.98, 1.95]< 10%1 study (1/-)3.2 %NAnot evaluable important-
serious adverse events 0.17 [0.02, 1.49]< 10%1 study (1/-)94.4 %NAnot evaluable important-
adverse events 0.98 [0.40, 2.38]< 10%1 study (1/-)51.9 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.