Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

RECOVERY (AZI, Horby)
  NCT04381936		 RCTazithromycinstandard of careCOVID 19 hospitalizedsome concern
2582/5181 inconclusive
  • inconclusive 3 % decrease in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
Sekhavati
  IRCT20200415047092N1		 RCTazithromycinstandard of careCOVID 19 hospitalizedsome concern
56/55 inconclusive
  • inconclusive 51 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias

COVID-19 mild to moderate meta-analysis

Rashad A (AZI vs SoC) RCTazithromycinstandard of careCOVID-19 mild to moderatesome concern
107/99 inconclusive
    COALITION I Covid-19 Brazil (AZI, Cavalcanti)
          NCT04322123    		 RCTazithromycinstandard of careCOVID-19 mild to moderatesome concern
    		172/159 inconclusive
    • inconclusive 18 % decrease in clinical improvement,clinical improvement (14-day) (PE) with a moderate degree of certainty due to some concern in risk of bias

    COVID-19 severe or critically meta-analysis

    COALITION II Covid-19 Brazil (Furtado)
          NCT04321278    		 RCTazithromycinstandard of careCOVID-19 severe or criticallysome concern
    		214/183 safety concern
    • inconclusive 26 % decrease in clinical improvement,clinical improvement (14-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
    • statistically significant 6 % decrease in clinical improvement (7-day) with a moderate degree of certainty due to some concern in risk of bias
    4 studies excluded by filtering options (0 RCT / 4 OBS)

    PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
    Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

     

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