immunoglobulin therapy - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.90 [0.40, 2.03]< 10%3 studies (3/-)59.7 %some concernnot evaluable moderatecrucial-
deaths 0.90 [0.40, 2.03]< 10%3 studies (3/-)59.7 %some concernnot evaluable moderatecrucial-
mechanical ventilation 0.61 [0.08, 4.52]< 176%2 studies (2/-)68.3 %some concernnot evaluable moderateimportant-
radiologic improvement (14-day) 2.33 [0.45, 12.00]> 10%1 study (1/-)84.4 %some concernnot evaluable moderateimportant-
viral clearance 36.42 [10.85, 122.18]> 10%1 study (1/-)100.0 %some concernnot evaluable moderateimportant-
viral clearance by day 14 36.42 [10.85, 122.18]> 10%1 study (1/-)100.0 %some concernnot evaluable moderateimportant-
ICU admission 0.56 [0.18, 1.74]< 10%1 study (1/-)84.3 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 0.49 [0.02, 15.10]< 10%1 study (1/-)65.4 %some concernnot evaluable moderateimportant-
adverse events 1.34 [0.56, 3.18]< 10%2 studies (2/-)25.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.