favipiravir - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.69 [0.11, 4.29]< 10%4 studies (4/-)65.5 %some concernnot evaluable moderatecrucial-
clinical improvement 1.65 [1.28, 2.13]> 10%5 studies (5/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.26 [1.04, 1.53]> 10%3 studies (3/-)99.0 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.32 [0.86, 2.03]> 170%2 studies (2/-)89.4 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 1.62 [1.15, 2.28]> 10%2 studies (2/-)99.7 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.58 [1.25, 2.01]> 10%3 studies (3/-)100.0 %some concernnot evaluable moderateimportant-
hospital discharge 1.41 [0.97, 2.03]> 10%1 study (1/-)96.6 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.06 [0.01, 0.83]< 10%1 study (1/-)98.2 %some concernnot evaluable moderateimportant-
mechanical ventilation (time to event analysis only) 0.06 [0.01, 0.83]< 10%1 study (1/-)98.2 %some concernnot evaluable moderateimportant-
viral clearance 1.75 [1.07, 2.87]> 163%6 studies (6/-)98.7 %some concernnot evaluable moderateimportant-
viral clearance (time to event analysis only) 1.32 [1.03, 1.69]> 10%2 studies (2/-)98.6 %some concernnot evaluable moderateimportant-
viral clearance by day 14 1.12 [0.48, 2.63]> 132%3 studies (3/-)60.4 %some concernnot evaluable moderateimportant-
viral clearance by day 7 1.44 [0.78, 2.65]> 161%3 studies (3/-)87.5 %some concernnot evaluable moderateimportant-
ICU admission 5.43 [0.21, 139.89]< 10%1 study (1/-)15.7 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 2.73 [0.55, 13.60]< 10%4 studies (4/-)11.1 %some concernnot evaluable moderateimportant-
adverse events 3.78 [1.07, 13.38]< 191%4 studies (4/-)2.0 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.