remdesivir - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.91 [0.79, 1.05]< 10%5 studies (5/-)89.7 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.86 [0.65, 1.14]< 149%2 studies (2/-)85.1 %some concernnot evaluable moderatecrucial-
clinical improvement 1.32 [1.16, 1.50]> 10%4 studies (4/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.49 [1.13, 1.98]> 10%3 studies (3/-)99.7 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.64 [1.17, 2.29]> 10%3 studies (3/-)99.8 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 1.23 [0.93, 1.64]> 10%3 studies (3/-)92.6 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.23 [0.87, 1.74]> 10%1 study (1/-)87.7 %lownot evaluable highimportant-
death or ventilation 0.97 [0.85, 1.10]< 10%1 study (1/-)67.8 %some concernnot evaluable moderateimportant-
ventilation 1.04 [0.87, 1.23]< 10%1 study (1/-)33.9 %some concernnot evaluable moderateimportant-

safety endpoints 00

AE leading to drug discontinuation 2.43 [0.79, 7.45]< 10%1 study (1/-)6.0 %lownot evaluable highimportant-
serious adverse events 0.71 [0.55, 0.92]< 10%2 studies (2/-)99.5 %some concernnot evaluable moderateimportant-
deep vein thrombosis 0.62 [0.23, 1.64]< 10%2 studies (2/-)83.1 %some concernnot evaluable moderatenon important-
elevated liver enzymes 0.58 [0.34, 0.97]< 16%2 studies (2/-)98.1 %some concernnot evaluable moderatenon important-
hyperbilirubinemia 0.97 [0.48, 1.93]< 10%2 studies (2/-)53.8 %some concernnot evaluable moderatenon important-
pulmonary embolism 0.82 [0.20, 3.29]< 10%2 studies (2/-)61.1 %some concernnot evaluable moderatenon important-
renal impairment 1.02 [0.64, 1.61]< 10%2 studies (2/-)47.2 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.