patient subgroup...
age >= 55 yr age >= 65 yr critical disease omicron variant BA.1 (B.1.1.529) solid organ transplant recipients subjects at risk
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
Immunostimulants drugs - versus control - for COVID 19 hospitalized
method
abbreviations
Outcome
Relative effect 95%CI
LoD
Trt. better when
I2
k (RCT/OBS)
Bayesian probability
Overall ROB
Publication bias
Degree of certainty
Endpoint importance
Published MA
00 death D28 0.91 [0.83, 0.99]< 1 8% 33 studies (33/-) 98.6 % some concern critical moderate crucial - death or transfer to ICU 0.65 [0.35, 1.22]< 1 0% 1 study (1/-) 90.9 % NA not evaluable crucial - deaths 0.91 [0.84, 0.98]< 1 9% 56 studies (56/-) 99.3 % some concern critical moderate crucial 1 deaths (time to event analysis only) 0.91 [0.74, 1.11]< 1 8% 10 studies (10/-) 82.4 % some concern low moderate crucial - clinical deterioration 0.84 [0.69, 1.04]< 1 10% 6 studies (6/-) 94.7 % some concern not evaluable moderate important - clinical improvement 1.08 [0.96, 1.22]> 1 36% 16 studies (16/-) 90.4 % some concern low moderate important - clinical improvement (14-day) 1.37 [0.69, 2.72]> 1 56% 4 studies (4/-) 81.3 % some concern not evaluable moderate important - clinical improvement (28-day) 1.61 [0.96, 2.70]> 1 67% 6 studies (6/-) 96.3 % some concern serious moderate important - clinical improvement (7-day) 1.10 [0.80, 1.51]> 1 35% 4 studies (4/-) 72.6 % some concern not evaluable moderate important - clinical improvement (time to event analysis only) 1.16 [0.96, 1.40]> 1 42% 9 studies (9/-) 93.9 % some concern serious moderate important - death or ventilation 0.94 [0.87, 1.03]< 1 59% 9 studies (9/-) 90.3 % some concern not evaluable moderate important - hospital discharge 1.09 [0.98, 1.21]> 1 55% 8 studies (8/-) 94.5 % some concern not evaluable moderate important - hospitalization 1.00 [0.14, 7.34]< 1 0% 1 study (1/-) 50.0 % NA not evaluable important - mechanical ventilation 0.82 [0.64, 1.06]< 1 21% 12 studies (12/-) 93.5 % some concern critical moderate important 1 mechanical ventilation (time to event analysis only) 0.97 [0.62, 1.52]< 1 0% 2 studies (2/-) 55.5 % some concern not evaluable moderate important - radiologic improvement (14-day) 2.33 [0.45, 12.00]> 1 0% 1 study (1/-) 84.4 % NA not evaluable important - viral clearance 2.71 [0.82, 8.92]> 1 88% 6 studies (6/-) 94.9 % some concern not evaluable moderate important - viral clearance (time to event analysis only) 0.81 [0.56, 1.18]> 1 0% 1 study (1/-) 13.7 % NA not evaluable important - viral clearance by day 14 1.08 [0.07, 16.52]> 1 97% 5 studies (5/-) 52.2 % some concern not evaluable moderate important - viral clearance by day 7 1.59 [0.67, 3.76]> 1 73% 4 studies (4/-) 85.4 % some concern not evaluable moderate important - ICU admission 0.60 [0.41, 0.88]< 1 0% 7 studies (7/-) 99.6 % some concern not evaluable moderate non important - recovery 1.12 [0.97, 1.28]> 1 7% 4 studies (4/-) 94.3 % low not evaluable high non important - 00 composite safety outcome 1.56 [0.78, 3.11]< 1 0% 1 study (1/-) 10.3 % NA not evaluable important - serious adverse events 1.16 [0.98, 1.36]< 1 12% 10 studies (10/-) 3.9 % some concern low moderate important - superinfection 0.18 [0.02, 1.59]< 1 0% 1 study (1/-) 93.8 % NA not evaluable important - adverse events 1.13 [0.91, 1.40]< 1 0% 6 studies (6/-) 12.9 % some concern not evaluable moderate non important -
LoD: level of statistical demonstration:
