Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials
Summary Endpoints
     
Demonstrated or suggested benefit Inconclusive results Uncertain results Safety results
chloroquine and derivatives15noneinconclusive results for: deaths; confirmed COVID (any severity); conversion to SARS-CoV- 2–positive status via NP swab; death or ventilation; hospitalization; symptomatic Covid-19; asymptomatic COVID case; infection (PCR positive symptomatic or not); serious adverse events; adverse events--
ivermectin4noneinconclusive results for: deaths; serious adverse events; adverse events

suggested 73 % decrease in conversion to SARS-CoV- 2–positive status via NP swab but the degree if certainty is unassessable

suggested 95 % decrease in new illness compatible with Covid-19 but with a low degree of certainty due to high risk of bias

-
bromhexine1noneinconclusive results for: deaths; hospitalization; new illness compatible with Covid-19 ; ICU admission--
nirmatrelvir / ritonavir (Paxlovid)1none---
Amantadine0- - - -
ASC09/ritonavir0- - - -
azithromycin0- - - -
azvudine0- - - -
baloxavir marboxil0- - - -
carrimycin0- - - -
danoprevir / ritonavir0- - - -
darunavir cobicistat0- - - -
doxycycline0- - - -
Emtricitabine/tenofovir plus colchicine plus rosuvastatin0- - - -
Ensitrelvir (XOCOVA)0- - - -
favipiravir 0- - - -
favipiravir plus interferon0- - - -
fluvoxamine0- - - -
hydroxychloroquine plus macrolides0- - - -
Interferon plus lopinavir/ritonavir0- - - -
leronlimab0- - - -
lopinavir / ritonavir plus ribavirin0- - - -
lopinavir/ritonavir0- - - -
lopinavir/ritonavir plus chloroquine0- - - -
Lopinavir/ritonavir plus hydroxychloroquine0- - - -
lopinavir/ritonavir plus interferon ß-1a0- - - -
lopinavir/ritonavir, ribavirin and interferon beta-1b0- - - -
molnupiravir0- - - -
niclosamide0- - - -
nitazoxanide0- - - -
opaganib0- - - -
oseltamivir0- - - -
oseltamivir plus chloroquin0- - - -
remdesivir0- - - -
ribavirin0- - - -
ritonavir0- - - -
sofosbuvir0- - - -
sofosbuvir and daclatasvir0- - - -
sofosbuvir and ledipasvir0- - - -
tenofovir/emtricitabine0- - - -
tenofovir/emtricitabine plus hydroxychloroquine0- - - -
tranexamic acid0- - - -
tranilast0- - - -
triazavirin0- - - -
umifenovir (arbidol)0- - - -
zinc0- - - -

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