Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
chloroquine and derivatives38 1.34 [0.96; 1.87], 4 RCTs, I2=18%
inconclusive result
0.98 [0.64; 1.52], 3 RCTs, I2=26%
inconclusive result
1.10 [0.99; 1.22], 17 RCTs, I2=0%
inconclusive result
0.83 [0.57; 1.21], 2 RCTs, I2=0%
inconclusive result
Renin-angiotensin-system-acting agents8- OBS 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
0.97 [0.38; 2.50], 1 RCT, I2=0%
inconclusive result
-
hydroxychloroquine plus macrolides7- 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
0.64 [0.18; 2.24], 1 RCT, I2=0%
inconclusive result
-
remdesevir6 1.32 [1.16; 1.50], 4 RCTs, I2=0% demonstrated
moderate degree of certainty
- 0.91 [0.79; 1.05], 5 RCTs, I2=0%
inconclusive result
-
lopinavir/ritonavir4 1.32 [0.99; 1.78], 2 RCTs, I2=0%
inconclusive result
3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
1.02 [0.91; 1.14], 3 RCTs, I2=0%
inconclusive result
1.28 [0.19; 8.76], 1 RCT, I2=0%
inconclusive result
azithromycin2- 1.36 [0.94; 1.97], 1 RCT, I2=0%
inconclusive result
1.08 [0.79; 1.47], 1 RCT, I2=0%
inconclusive result
-
interferon2 2.19 [1.03; 4.67], 1 RCT, I2=0%
unassessable degree of certainty
- 1.16 [0.96; 1.40], 1 RCT, I2=0%
inconclusive result
-
favipiravir 1 1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
---
umifenovir (arbidol)1 1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
- 2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
fluvoxamine0----
ivermectin0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
lopinavir/ritonavir, ribavirin and interferon beta-1b0----
meplazumab0----
nitazoxanide0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----