Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
chloroquine and derivatives49 1.03 [0.79; 1.35], 6 RCTs, I2=0%
inconclusive result
1.14 [0.91; 1.42], 4 RCTs, I2=0%
inconclusive result
1.06 [0.96; 1.17], 35 RCTs, I2=0%
inconclusive result
0.96 [0.76; 1.21], 5 RCTs, I2=0%
inconclusive result
ivermectin32 0.48 [0.30; 0.77], 5 RCTs, I2=0%
low degree of certainty
1.22 [0.93; 1.61], 4 RCTs, I2=15%
inconclusive result
0.41 [0.23; 0.76], 11 RCTs, I2=40%
low degree of certainty
0.92 [0.77; 1.09], 2 RCTs, I2=0%
inconclusive result
favipiravir 15- 1.61 [1.28; 2.03], 6 RCTs, I2=0%
moderate degree of certainty
0.63 [0.15; 2.71], 5 RCTs, I2=0%
inconclusive result
1.64 [1.10; 2.44], 7 RCTs, I2=56%
low degree of certainty
Renin-angiotensin-system-acting agents11 OBS 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
- 0.76 [0.42; 1.35], 4 RCTs, I2=0%
inconclusive result
-
azithromycin10 1.07 [0.63; 1.82], 1 RCT, I2=0%
inconclusive result
0.92 [0.70; 1.21], 3 RCTs, I2=53%
inconclusive result
0.99 [0.83; 1.18], 6 RCTs, I2=11%
inconclusive result
OBS 715.00 [12.94; 39513.71], 1 study, I2=0%
unassessable degree of certainty
hydroxychloroquine plus macrolides9 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
- 0.67 [0.27; 1.69], 3 RCTs, I2=0%
inconclusive result
0.64 [0.42; 0.98], 2 RCTs, I2=0%
statistically significant harm
remdesivir8 0.95 [0.55; 1.64], 1 RCT, I2=0%
inconclusive result
1.16 [0.99; 1.37], 6 RCTs, I2=64% demonstrated
inconclusive result
0.81 [0.66; 0.99], 8 RCTs, I2=16%
moderate degree of certainty
-
lopinavir/ritonavir6 3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
1.72 [0.98; 3.01], 3 RCTs, I2=64%
inconclusive result
1.01 [0.91; 1.13], 6 RCTs, I2=0%
inconclusive result
1.95 [0.73; 5.23], 3 RCTs, I2=72% demonstrated
inconclusive result
sofosbuvir and daclatasvir5-- 0.97 [0.58; 1.63], 3 RCTs, I2=12%
inconclusive result
-
umifenovir (arbidol)5 0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
1.00 [0.18; 5.59], 2 RCTs, I2=0%
inconclusive result
2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
nitazoxanide3 1.02 [0.29; 3.58], 1 RCT, I2=0%
inconclusive result
0.81 [0.52; 1.27], 1 RCT, I2=0%
inconclusive result
1.02 [0.02; 51.70], 1 RCT, I2=0%
inconclusive result
-
doxycycline2 0.44 [0.24; 0.78], 2 RCTs, I2=0%
low degree of certainty
1.89 [1.06; 3.38], 1 RCT, I2=0%
low degree of certainty
0.39 [0.11; 1.42], 2 RCTs, I2=0%
inconclusive result
-
sofosbuvir2----
sofosbuvir and ledipasvir2----
azithromycin plus hydroxychloroquine1-- 0.45 [0.04; 5.10], 1 RCT, I2=0%
inconclusive result
-
azvudine1-- 1.00 [0.02; 55.80], 1 RCT, I2=0%
inconclusive result
28.50 [1.27; 640.66], 1 RCT, I2=0%
moderate degree of certainty
baloxavir marboxil1-- 1.00 [0.02; 55.80], 1 RCT, I2=0%
inconclusive result
-
darunavir cobicistat1 2.07 [0.06; 66.79], 1 RCT, I2=0%
inconclusive result
- 1.00 [0.02; 53.89], 1 RCT, I2=0%
inconclusive result
0.82 [0.36; 1.87], 1 RCT, I2=0%
inconclusive result
favipiravir plus interferon1-- 0.83 [0.23; 2.96], 1 RCT, I2=0%
inconclusive result
-
fluvoxamine1 0.07 [0.00; 1.26], 1 RCT, I2=0% demonstrated
inconclusive result
---
lopinavir/ritonavir plus interferon ß-1a1----
lopinavir/ritonavir, ribavirin and interferon beta-1b1- 3.92 [1.66; 9.24], 1 RCT, I2=0%
moderate degree of certainty
0.47 [0.01; 24.30], 1 RCT, I2=0%
inconclusive result
4.37 [1.86; 10.25], 1 RCT, I2=0% demonstrated
moderate degree of certainty
oseltamivir1----
ASC09/ritonavir0----
carrimycin0----
danoprevir / ritonavir0----
Interferon plus lopinavir/ritonavir0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
molnupiravir0----
opaganib0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----