metaOBS - - Real World Evidence KB

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament	Trials	Summary Endpoints
Treament	Trials	Demonstrated or suggested benefit	Inconclusive results	Uncertain results	Safety results
Vitamin D	8	demonstrated 83 % decrease in ICU admission	inconclusive results for: 14-days deaths; death D28; deaths; death or ventilation; hospital discharge; mechanical ventilation; serious adverse events; adverse events	suggested 6.3-fold increase in viral clearance but the degree if certainty is unassessable	-
vitamin C	3	none	inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (21-day); clinical improvement (7-day); clinical improvement (time to event analysis only); mechanical ventilation; viral clearance (time to event analysis only); serious adverse events; adverse events	suggested 5.5-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable	-