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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

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Our approach
     
Treament Trials
Demonstrated or suggested benefit Inconclusive results Uncertain results Safety results
14

demonstrated 14 % decrease in deaths

suggested 10 % increase in hospital discharge

inconclusive results for: deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; ventilation; serious adverse events; superinfection--
6

demonstrated 32 % increase in clinical improvement

suggested 49 % increase in clinical improvement (14-day)

suggested 64 % increase in clinical improvement (28-day)

suggested 29 % increase in clinical improvement (7-day)

suggested 29 % decrease in serious adverse events

suggested 42 % decrease in elevated liver enzymes

inconclusive results for: deaths; deaths (time to event analysis only); clinical improvement (time to event analysis only); death or ventilation; ventilation; AE leading to drug discontinuation; deep vein thrombosis; hyperbilirubinemia; pulmonary embolism; renal impairment--
35 noneinconclusive results for: deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (time to event analysis only); death or ventilation; PCR-negative conversion; PCR-negative conversion (14-day); PCR-negative conversion (time to event analysis only); radiologic improvement (7-day); ventilation; ventilation (time to event analysis only); ICU admission; cardiac arrest; abnormal ECG findings; adverse events; arrhythmia--
17

demonstrated 52 % decrease in clinical deterioration

inconclusive results for: death or transfer to ICU; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (28-day); death or ventilation; PCR-negative conversion (7-day); ventilation; ICU admission; off oxygenation; serious adverse events--
8

demonstrated 3.4-fold increase in clinical improvement (time to event analysis only)

inconclusive results for: deaths; clinical improvement; death or ventilation; hospital discharge; PCR-negative conversion (time to event analysis only); ventilation; ICU admission--
18

demonstrated 25 % increase in clinical improvement

demonstrated 38 % decrease in death or ventilation

inconclusive results for: death or transfer to ICU; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); hospital discharge; ventilation; ICU admission; superinfection--
6

demonstrated 76 % increase in clinical improvement

inconclusive results for: deaths; deaths (time to event analysis only); death or ventilation; ventilation; off oxygenation--
6

suggested 94 % increase in clinical improvement (14-day)

inconclusive results for: death or transfer to ICU; deaths; clinical deterioration; clinical improvement; clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); hospital discharge; PCR-negative conversion; PCR-negative conversion (14-day); PCR-negative conversion (7-day); PCR-negative conversion (time to event analysis only); radiologic improvement (14-day); radiologic improvement (7-day); serious adverse events--
3 noneinconclusive results for: deaths; clinical deterioration; ventilation--
6

demonstrated 82 % decrease in ICU admission

inconclusive results for: deaths; death or ventilation; PCR-negative conversion--
1 none---

Demonstrated: statistically demonstrated that is statistically significant with a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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