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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

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Our approach
     
Treament Trials
Demonstrated or suggested benefit Inconclusive results Uncertain results Safety results
corticosteroids 13

demonstrated 15 % decrease in deaths

suggested 10 % increase in hospital discharge

inconclusive results for: deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); clinical worsening; death or ventilation; ventilation; superinfection; serious adverse events--
remdesivir 6

demonstrated 32 % increase in clinical improvement

suggested 49 % increase in clinical improvement (14-day)

suggested 64 % increase in clinical improvement (28-day)

suggested 29 % increase in clinical improvement (7-day)

suggested 29 % decrease in serious adverse events

inconclusive results for: deaths; deaths (time to event analysis only); clinical improvement (time to event analysis only); death or ventilation; ventilation; AE leading to drug discontinuation--
hydroxychloroquine 32 noneinconclusive results for: deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (time to event analysis only); clinical worsening; death or ventilation; PCR-negative conversion; PCR-negative conversion (14-day); PCR-negative conversion (time to event analysis only); radiologic improvement (7-day); ventilation; ventilation (time to event analysis only); ICU admission; cardiac arrest; abnormal ECG findings; adverse events; arrhythmia--
convalescent plasma treatment 12 noneinconclusive results for: death or transfer to ICU; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (28-day); clinical worsening; PCR-negative conversion (7-day); serious adverse events--
interferon 6

demonstrated 3.4-fold increase in clinical improvement (time to event analysis only)

inconclusive results for: deaths; clinical improvement; clinical worsening; death or ventilation; hospital discharge; PCR-negative conversion (time to event analysis only); ventilation; ICU admission; adverse events--
anti-interleukin-6 22

demonstrated 38 % decrease in death or ventilation

inconclusive results for: death or transfer to ICU; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (28-day); clinical improvement (time to event analysis only); clinical worsening; hospital discharge; ventilation; ICU admission; off oxygenation; superinfection--
lopinavir/ritonavir 5

suggested 65 % increase in clinical improvement (14-day)

demonstrated 3.2-fold increase in PCR-negative conversion

demonstrated 4.4-fold increase in PCR-negative conversion (time to event analysis only)

suggested 49 % decrease in serious adverse events

inconclusive results for: death or transfer to ICU; deaths; clinical improvement; clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); clinical worsening; hospital discharge; PCR-negative conversion (14-day); PCR-negative conversion (7-day); radiologic improvement (14-day); radiologic improvement (7-day); adverse events--
anakinra 2 noneinconclusive results for: death or transfer to ICU; clinical worsening--
colchicine 3 noneinconclusive results for: deaths; clinical worsening; ventilation--
anticoagulant 2 noneinconclusive results for: deaths; deaths (time to event analysis only)--
Vitamin D 5

demonstrated 97 % decrease in ICU admission

inconclusive results for: deaths; death or ventilation; PCR-negative conversion--

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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