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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

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Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Interactive explorer of NMA results

9RECOVERY dexamethasone, 2020 CODEX (Tomazini), 2020 REMAP-CAP, fixed 7-day course, 2020 REMAP-CAP, shock-dependent course, 2020 CAPE-COVID, 2020 Tang X, 2020 Steroids-SARI, 2020 DEXA-COVID19, 2020 COVID STEROID, 20201Ranjbar, 20214CAP-China (Wang et al.), 2020 NIH NIAID ACTT-1, 2020 GS-US-540-5774, 10 days, 2020 GS-US-540-5774, 5 days, 202011RECOVERY, 2020 Abd-Elsalam, 2020 TEACH, 2020 HYCOVID, 2020 HC-nCoV (Shanghai), 2020 Chen, 2020 NO COVID-19 (Lyngbakken), 2020 SOLIDARITY (WHO study) HCQ, 2020 Coalition Covid-19 Brazil I (Cavalcanti)-Hydroxychloroquine, 2020 ORCHID, 2020 Gonzalez_HCQ, 20207Li, 2020 ConCOVID (Gharbharan et al.), 2020 ConPlas-19, 2020 PlasmAr, 2020 Libster, 2020 RECOVERY (plasma), 2021 O’Donnell, 20211Balcells, 20206SOLIDARITY (interferon), 2020 Rahmani, 2020 Synairgen SG016, 2020 Darazam (COVIFERON Interferon beta-1a), 2021 Darazam (COVIFERON Interferon beta-1b), 2021 Fu, 20202Li, 2021 Darazam, 20218COVACTA (Rosas), 2020 CORIMUNO-19, 2020 BACC Bay Tocilizumab Trial, 2020 EMPACTA, 2020 REMAP-CAP tocilizumab, 2021 RCT-TCZ-COVID-19, 2021 Veiga, 2021 RECOVERY, 20213REMAP-CAP sarilumab, 2021 Lescure (Sarilumab 400mg), 2021 Lescure (Sarilumab 200mg), 20212Salehzadeh, 2020 GRECCO-19, 20203Hashim A, 2020 Kirti, 2021 Gonzalez_IVER, 2020colchicine vs. control 0.31 [0.04; 2.16]0.31 [0.04;2.16]colchicine vs. control 0.31 [0.04; 2.16]colchicine vs. convalescent plasma treatment 0.33 [0.05; 2.29]0.33 [0.05;2.29]colchicine vs. convalescent plasma treatment 0.33 [0.05; 2.29]colchicine vs. corticosteroids 0.34 [0.05; 2.35]0.34 [0.05;2.35]colchicine vs. corticosteroids 0.34 [0.05; 2.35]colchicine vs. hydroxychloroquine 0.29 [0.04; 2.00]0.29 [0.04;2.00]colchicine vs. hydroxychloroquine 0.29 [0.04; 2.00]colchicine vs. interferon 0.29 [0.04; 2.07]0.29 [0.04;2.07]colchicine vs. interferon 0.29 [0.04; 2.07]colchicine vs. ivermectin 0.56 [0.07; 4.79]0.56 [0.07;4.79]colchicine vs. ivermectin 0.56 [0.07; 4.79]colchicine vs. remdesivir 0.48 [0.07; 3.47]0.48 [0.07;3.47]colchicine vs. remdesivir 0.48 [0.07; 3.47]colchicine vs. sarilumab 0.40 [0.05; 2.95]0.40 [0.05;2.95]colchicine vs. sarilumab 0.40 [0.05; 2.95]colchicine vs. tocilizumab 0.35 [0.05; 2.48]0.35 [0.05;2.48]colchicine vs. tocilizumab 0.35 [0.05; 2.48]control vs. colchicine 3.23 [0.46; 22.49]3.23 [0.46;22.49]control vs. colchicine 3.23 [0.46; 22.49]control vs. convalescent plasma treatment 1.05 [0.91; 1.22]1.05 [0.91;1.22]control vs. convalescent plasma treatment 1.05 [0.91; 1.22]control vs. corticosteroids 1.09 [0.98; 1.20]1.09 [0.98;1.20]control vs. corticosteroids 1.09 [0.98; 1.20]control vs. hydroxychloroquine 0.92 [0.79; 1.07]0.92 [0.79;1.07]control vs. hydroxychloroquine 0.92 [0.79; 1.07]control vs. interferon 0.95 [0.76; 1.18]0.95 [0.76;1.18]control vs. interferon 0.95 [0.76; 1.18]control vs. ivermectin 1.81 [0.72; 4.51]1.81 [0.72;4.51]control vs. ivermectin 1.81 [0.72; 4.51]control vs. remdesivir remdesivir better 1.55 [1.08; 2.24]1.55 [1.08;2.24]control vs. remdesivir remdesivir better 1.55 [1.08; 2.24]control vs. sarilumab 1.28 [0.78; 2.11]1.28 [0.78;2.11]control vs. sarilumab 1.28 [0.78; 2.11]control vs. tocilizumab 1.14 [0.99; 1.32]1.14 [0.99;1.32]control vs. tocilizumab 1.14 [0.99; 1.32]convalescent plasma treatment vs. colchicine 3.07 [0.44; 21.49]3.07 [0.44;21.49]convalescent plasma treatment vs. colchicine 3.07 [0.44; 21.49]convalescent plasma treatment vs. control 0.95 [0.82; 1.10]0.95 [0.82;1.10]convalescent plasma treatment vs. control 0.95 [0.82; 1.10]convalescent plasma treatment vs. corticosteroids 1.03 [0.86; 1.24]1.03 [0.86;1.24]convalescent plasma treatment vs. corticosteroids 1.03 [0.86; 1.24]convalescent plasma treatment vs. hydroxychloroquine 0.87 [0.71; 1.08]0.87 [0.71;1.08]convalescent plasma treatment vs. hydroxychloroquine 0.87 [0.71; 1.08]convalescent plasma treatment vs. interferon 0.90 [0.69; 1.18]0.90 [0.69;1.18]convalescent plasma treatment vs. interferon 0.90 [0.69; 1.18]convalescent plasma treatment vs. ivermectin 1.72 [0.68; 4.34]1.72 [0.68;4.34]convalescent plasma treatment vs. ivermectin 1.72 [0.68; 4.34]convalescent plasma treatment vs. remdesivir 1.48 [0.99; 2.19]1.48 [0.99;2.19]convalescent plasma treatment vs. remdesivir 1.48 [0.99; 2.19]convalescent plasma treatment vs. sarilumab 1.22 [0.72; 2.05]1.22 [0.72;2.05]convalescent plasma treatment vs. sarilumab 1.22 [0.72; 2.05]convalescent plasma treatment vs. tocilizumab 1.08 [0.88; 1.34]1.08 [0.88;1.34]convalescent plasma treatment vs. tocilizumab 1.08 [0.88; 1.34]corticosteroids vs. colchicine 2.97 [0.43; 20.78]2.97 [0.43;20.78]corticosteroids vs. colchicine 2.97 [0.43; 20.78]corticosteroids vs. control 0.92 [0.83; 1.02]0.92 [0.83;1.02]corticosteroids vs. control 0.92 [0.83; 1.02]corticosteroids vs. convalescent plasma treatment 0.97 [0.81; 1.16]0.97 [0.81;1.16]corticosteroids vs. convalescent plasma treatment 0.97 [0.81; 1.16]corticosteroids vs. hydroxychloroquine 0.85 [0.71; 1.02]0.85 [0.71;1.02]corticosteroids vs. hydroxychloroquine 0.85 [0.71; 1.02]corticosteroids vs. interferon 0.87 [0.68; 1.12]0.87 [0.68;1.12]corticosteroids vs. interferon 0.87 [0.68; 1.12]corticosteroids vs. ivermectin 1.66 [0.66; 4.18]1.66 [0.66;4.18]corticosteroids vs. ivermectin 1.66 [0.66; 4.18]corticosteroids vs. remdesivir 1.43 [0.98; 2.10]1.43 [0.98;2.10]corticosteroids vs. remdesivir 1.43 [0.98; 2.10]corticosteroids vs. sarilumab 1.18 [0.71; 1.97]1.18 [0.71;1.97]corticosteroids vs. sarilumab 1.18 [0.71; 1.97]corticosteroids vs. tocilizumab 1.05 [0.88; 1.26]1.05 [0.88;1.26]corticosteroids vs. tocilizumab 1.05 [0.88; 1.26]hydroxychloroquine vs. colchicine 3.51 [0.50; 24.58]3.51 [0.50;24.58]hydroxychloroquine vs. colchicine 3.51 [0.50; 24.58]hydroxychloroquine vs. control 1.09 [0.94; 1.26]1.09 [0.94;1.26]hydroxychloroquine vs. control 1.09 [0.94; 1.26]hydroxychloroquine vs. convalescent plasma treatment 1.14 [0.93; 1.41]1.14 [0.93;1.41]hydroxychloroquine vs. convalescent plasma treatment 1.14 [0.93; 1.41]hydroxychloroquine vs. corticosteroids 1.18 [0.98; 1.42]1.18 [0.98;1.42]hydroxychloroquine vs. corticosteroids 1.18 [0.98; 1.42]hydroxychloroquine vs. interferon 1.03 [0.78; 1.35]1.03 [0.78;1.35]hydroxychloroquine vs. interferon 1.03 [0.78; 1.35]hydroxychloroquine vs. ivermectin 1.96 [0.78; 4.96]1.96 [0.78;4.96]hydroxychloroquine vs. ivermectin 1.96 [0.78; 4.96]hydroxychloroquine vs. remdesivir remdesivir better 1.69 [1.13; 2.51]1.69 [1.13;2.51]hydroxychloroquine vs. remdesivir remdesivir better 1.69 [1.13; 2.51]hydroxychloroquine vs. sarilumab 1.39 [0.83; 2.35]1.39 [0.83;2.35]hydroxychloroquine vs. sarilumab 1.39 [0.83; 2.35]hydroxychloroquine vs. tocilizumab tocilizumab better 1.24 [1.01; 1.53]1.24 [1.01;1.53]hydroxychloroquine vs. tocilizumab tocilizumab better 1.24 [1.01; 1.53]interferon vs. colchicine 3.41 [0.48; 24.09]3.41 [0.48;24.09]interferon vs. colchicine 3.41 [0.48; 24.09]interferon vs. control 1.06 [0.84; 1.32]1.06 [0.84;1.32]interferon vs. control 1.06 [0.84; 1.32]interferon vs. convalescent plasma treatment 1.11 [0.85; 1.46]1.11 [0.85;1.46]interferon vs. convalescent plasma treatment 1.11 [0.85; 1.46]interferon vs. corticosteroids 1.15 [0.90; 1.47]1.15 [0.90;1.47]interferon vs. corticosteroids 1.15 [0.90; 1.47]interferon vs. hydroxychloroquine 0.97 [0.74; 1.27]0.97 [0.74;1.27]interferon vs. hydroxychloroquine 0.97 [0.74; 1.27]interferon vs. ivermectin 1.91 [0.74; 4.90]1.91 [0.74;4.90]interferon vs. ivermectin 1.91 [0.74; 4.90]interferon vs. remdesivir remdesivir better 1.64 [1.07; 2.52]1.64 [1.07;2.52]interferon vs. remdesivir remdesivir better 1.64 [1.07; 2.52]interferon vs. sarilumab 1.36 [0.78; 2.34]1.36 [0.78;2.34]interferon vs. sarilumab 1.36 [0.78; 2.34]interferon vs. tocilizumab 1.21 [0.92; 1.58]1.21 [0.92;1.58]interferon vs. tocilizumab 1.21 [0.92; 1.58]ivermectin vs. colchicine 1.79 [0.21; 15.28]1.79 [0.21;15.28]ivermectin vs. colchicine 1.79 [0.21; 15.28]ivermectin vs. control 0.55 [0.22; 1.38]0.55 [0.22;1.38]ivermectin vs. control 0.55 [0.22; 1.38]ivermectin vs. convalescent plasma treatment 0.58 [0.23; 1.47]0.58 [0.23;1.47]ivermectin vs. convalescent plasma treatment 0.58 [0.23; 1.47]ivermectin vs. corticosteroids 0.60 [0.24; 1.51]0.60 [0.24;1.51]ivermectin vs. corticosteroids 0.60 [0.24; 1.51]ivermectin vs. hydroxychloroquine 0.51 [0.20; 1.29]0.51 [0.20;1.29]ivermectin vs. hydroxychloroquine 0.51 [0.20; 1.29]ivermectin vs. interferon 0.52 [0.20; 1.34]0.52 [0.20;1.34]ivermectin vs. interferon 0.52 [0.20; 1.34]ivermectin vs. remdesivir 0.86 [0.32; 2.30]0.86 [0.32;2.30]ivermectin vs. remdesivir 0.86 [0.32; 2.30]ivermectin vs. sarilumab 0.71 [0.25; 2.01]0.71 [0.25;2.01]ivermectin vs. sarilumab 0.71 [0.25; 2.01]ivermectin vs. tocilizumab 0.63 [0.25; 1.59]0.63 [0.25;1.59]ivermectin vs. tocilizumab 0.63 [0.25; 1.59]remdesivir vs. colchicine 2.08 [0.29; 15.00]2.08 [0.29;15.00]remdesivir vs. colchicine 2.08 [0.29; 15.00]remdesivir vs. control remdesivir better 0.64 [0.45; 0.93]0.64 [0.45;0.93]remdesivir vs. control remdesivir better 0.64 [0.45; 0.93]remdesivir vs. convalescent plasma treatment 0.68 [0.46; 1.01]0.68 [0.46;1.01]remdesivir vs. convalescent plasma treatment 0.68 [0.46; 1.01]remdesivir vs. corticosteroids 0.70 [0.48; 1.02]0.70 [0.48;1.02]remdesivir vs. corticosteroids 0.70 [0.48; 1.02]remdesivir vs. hydroxychloroquine remdesivir better 0.59 [0.40; 0.88]0.59 [0.40;0.88]remdesivir vs. hydroxychloroquine remdesivir better 0.59 [0.40; 0.88]remdesivir vs. interferon remdesivir better 0.61 [0.40; 0.94]0.61 [0.40;0.94]remdesivir vs. interferon remdesivir better 0.61 [0.40; 0.94]remdesivir vs. ivermectin 1.16 [0.43; 3.12]1.16 [0.43;3.12]remdesivir vs. ivermectin 1.16 [0.43; 3.12]remdesivir vs. sarilumab 0.83 [0.44; 1.54]0.83 [0.44;1.54]remdesivir vs. sarilumab 0.83 [0.44; 1.54]remdesivir vs. tocilizumab 0.73 [0.49; 1.09]0.73 [0.49;1.09]remdesivir vs. tocilizumab 0.73 [0.49; 1.09]sarilumab vs. colchicine 2.52 [0.34; 18.68]2.52 [0.34;18.68]sarilumab vs. colchicine 2.52 [0.34; 18.68]sarilumab vs. control 0.78 [0.47; 1.28]0.78 [0.47;1.28]sarilumab vs. control 0.78 [0.47; 1.28]sarilumab vs. convalescent plasma treatment 0.82 [0.49; 1.38]0.82 [0.49;1.38]sarilumab vs. convalescent plasma treatment 0.82 [0.49; 1.38]sarilumab vs. corticosteroids 0.85 [0.51; 1.41]0.85 [0.51;1.41]sarilumab vs. corticosteroids 0.85 [0.51; 1.41]sarilumab vs. hydroxychloroquine 0.72 [0.43; 1.21]0.72 [0.43;1.21]sarilumab vs. hydroxychloroquine 0.72 [0.43; 1.21]sarilumab vs. interferon 0.74 [0.43; 1.27]0.74 [0.43;1.27]sarilumab vs. interferon 0.74 [0.43; 1.27]sarilumab vs. ivermectin 1.41 [0.50; 3.99]1.41 [0.50;3.99]sarilumab vs. ivermectin 1.41 [0.50; 3.99]sarilumab vs. remdesivir 1.21 [0.65; 2.25]1.21 [0.65;2.25]sarilumab vs. remdesivir 1.21 [0.65; 2.25]sarilumab vs. tocilizumab 0.89 [0.53; 1.50]0.89 [0.53;1.50]sarilumab vs. tocilizumab 0.89 [0.53; 1.50]tocilizumab vs. colchicine 2.83 [0.40; 19.83]2.83 [0.40;19.83]tocilizumab vs. colchicine 2.83 [0.40; 19.83]tocilizumab vs. control 0.88 [0.76; 1.01]0.88 [0.76;1.01]tocilizumab vs. control 0.88 [0.76; 1.01]tocilizumab vs. convalescent plasma treatment 0.92 [0.75; 1.14]0.92 [0.75;1.14]tocilizumab vs. convalescent plasma treatment 0.92 [0.75; 1.14]tocilizumab vs. corticosteroids 0.95 [0.80; 1.14]0.95 [0.80;1.14]tocilizumab vs. corticosteroids 0.95 [0.80; 1.14]tocilizumab vs. hydroxychloroquine tocilizumab better 0.81 [0.65; 0.99]0.81 [0.65;0.99]tocilizumab vs. hydroxychloroquine tocilizumab better 0.81 [0.65; 0.99]tocilizumab vs. interferon 0.83 [0.63; 1.08]0.83 [0.63;1.08]tocilizumab vs. interferon 0.83 [0.63; 1.08]tocilizumab vs. ivermectin 1.58 [0.63; 4.00]1.58 [0.63;4.00]tocilizumab vs. ivermectin 1.58 [0.63; 4.00]tocilizumab vs. remdesivir 1.36 [0.92; 2.02]1.36 [0.92;2.02]tocilizumab vs. remdesivir 1.36 [0.92; 2.02]tocilizumab vs. sarilumab 1.12 [0.67; 1.89]1.12 [0.67;1.89]tocilizumab vs. sarilumab 1.12 [0.67; 1.89]corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferontocilizumab sarilumabcolchicineivermectincontroldirect evidencenetwork meta-analysis

Click on treatment name to display related network evidence

T vs. C corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferontocilizumab sarilumabcolchicineivermectincontrol
corticosteroids---1.43
0.98; 2.10
0.85
0.71; 1.02
0.97
0.81; 1.16
0.87
0.68; 1.12
1.05
0.88; 1.26
1.18
0.71; 1.97
2.97
0.43; 20.78
1.66
0.66; 4.18
0.92
0.83; 1.02
remdesivir0.70
0.48; 1.02
---0.59
0.40; 0.88
0.68
0.46; 1.01
0.61
0.40; 0.94
0.73
0.49; 1.09
0.83
0.44; 1.54
2.08
0.29; 15.00
1.16
0.43; 3.12
0.64
0.45; 0.93
hydroxychloroquine1.18
0.98; 1.42
1.69
1.13; 2.51
---1.14
0.93; 1.41
1.03
0.78; 1.35
1.24
1.01; 1.53
1.39
0.83; 2.35
3.51
0.50; 24.58
1.96
0.78; 4.96
1.09
0.94; 1.26
convalescent plasma treatment1.03
0.86; 1.24
1.48
0.99; 2.19
0.87
0.71; 1.08
---0.90
0.69; 1.18
1.08
0.88; 1.34
1.22
0.72; 2.05
3.07
0.44; 21.49
1.72
0.68; 4.34
0.95
0.82; 1.10
interferon1.15
0.90; 1.47
1.64
1.07; 2.52
0.97
0.74; 1.27
1.11
0.85; 1.46
---1.21
0.92; 1.58
1.36
0.78; 2.34
3.41
0.48; 24.09
1.91
0.74; 4.90
1.06
0.84; 1.32
tocilizumab 0.95
0.80; 1.14
1.36
0.92; 2.02
0.81
0.65; 0.99
0.92
0.75; 1.14
0.83
0.63; 1.08
---1.12
0.67; 1.89
2.83
0.40; 19.83
1.58
0.63; 4.00
0.88
0.76; 1.01
sarilumab0.85
0.51; 1.41
1.21
0.65; 2.25
0.72
0.43; 1.21
0.82
0.49; 1.38
0.74
0.43; 1.27
0.89
0.53; 1.50
---2.52
0.34; 18.68
1.41
0.50; 3.99
0.78
0.47; 1.28
colchicine0.34
0.05; 2.35
0.48
0.07; 3.47
0.29
0.04; 2.00
0.33
0.05; 2.29
0.29
0.04; 2.07
0.35
0.05; 2.48
0.40
0.05; 2.95
---0.56
0.07; 4.79
0.31
0.04; 2.16
ivermectin0.60
0.24; 1.51
0.86
0.32; 2.30
0.51
0.20; 1.29
0.58
0.23; 1.47
0.52
0.20; 1.34
0.63
0.25; 1.59
0.71
0.25; 2.01
1.79
0.21; 15.28
---0.55
0.22; 1.38
control1.09
0.98; 1.20
1.55
1.08; 2.24
0.92
0.79; 1.07
1.05
0.91; 1.22
0.95
0.76; 1.18
1.14
0.99; 1.32
1.28
0.78; 2.11
3.23
0.46; 22.49
1.81
0.72; 4.51
---

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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