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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19

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Our approach


adjuvant therapies

anticoagulant 2

anticoagulant, curative dose 5

anticoagulant, pre-admission 3

anticoagulant, prophylactic dose 4

anticoagulation, intermediate prophylactic dose 1

Bivalirudin

enoxaparin

heparin at therapeutic dose 1

prasugrel

sulodexide

face mask

febuxostat

hydrogen-oxygen nebulizer

hyperbaric oxygen

nintedanib

pulmonary rehabilitation

respiratory support

anti-inflammatoty and immuno-therapy

anti-inflammatory therapies 1

anti GM-CSF

mavrilimumab 1

clarithromycine 2

colchicine 9

Colchicine plus rosuvastatin 1

IFX-1

naproxen, ibuprofen

non-steroidal anti-inflammatory drugs 8

Celecoxib 1

Ibuprofen 1

Indomethacin 2

selinexor

sodium aescinate

stem cells 3

tradipitant

Apilimod

corticosteroids 7

ciclesonide 2

dexamethasone 5

Dexamethasone 12mg 1

Hydrocortisone 4

low-dose corticosteroids

methylprednisolone 6

Immunostimulants drugs

anti-PD-1 antibody

CD24Fc

convalescent plasma treatment 47

Early convalescent plasma. 1

immunoglobulin therapy 4

inactivated mycobacterium vaccine

interferon 1

IFN beta-1a 4

high-dose IFN beta-1a 1

IFN beta-1b 2

IFN gamma 1

inhaled interferon

IFN alpha

pegylated interferon-α2b 2

recombinant super-compound interferon rSIFN-co 1

SNG001 inhaled interferon beta 1

interferon / TFF2 1

peginterferon 2

PNB001

Interleukin-2

levamisole

neutralizing antibody

bamlanivimab monotherapy 2

bamlanivimab plus etesevimab 3

bevacizumab

BRII-196 and BRII-198 (Brii Biosciences) 1

casirivimab and imdevimab (Ronapreve, REGN-COV2) 5

cilgavimab and tixagevimab (Evusheld)

equine polyclonal antibodies INM005 1

LY-CoV1404

regdanvimab (CT-P59 Celltrion) 2

sotrovimab (Xevudy) 2

XAV-19

rhG-CSF

Immunosuppressants drugs

adalimumab 1

anakinra 2

anti-interleukin-6

clazakizumab

Levilimab

sarilumab 5

sarilumab azithromycin hydroxychloroquine

sarilumab high dose (400mg) 1

sarilumab low dose (200mg) 1

siltuximab

tocilizumab 38

canakinumab 1

complement inhibitors

eculizumab

emapalumab

itolizumab 1

jakotinib

janus kinase (JAK) inhibitor

baricitinib 2

TD-0903

TD-0903 10mg 1

TD-0903 1mg 1

TD-0903 3mg 1

lenzilumab 1

pamrevlumab

tacrolimus

tetrandrine

thalidomide 1

inhaled corticosteroids

budesonide 2

Kinase inhibitors

acalabrutinib 2

imatinib 1

ruxolitinib 2

tofacitinib 1

leflunomide 1

meplazumab

pirfenidone

Polyinosinic-Polycytidylic Acid

sargramostim

statins

thymosin

antiandrogenic

5-alpha-reductase inhibitors

dutasteride 1

progesterone 1

proxalutamide 3

antiviral and associated therapy

ASC09/ritonavir

azithromycin 12

azvudine 1

baloxavir marboxil 1

bromhexine 3

carrimycin

chloroquine and derivatives 1

chloroquine 5

hydroxychloroquine 46

danoprevir / ritonavir

darunavir cobicistat 1

darunavir/cobicistat plus chloroquine

doxycycline 2

Emtricitabine/tenofovir plus colchicine plus rosuvastatin 1

favipiravir 16

favipiravir plus interferon 1

fluvoxamine 2

hydroxychloroquine plus macrolides 7

azithromycin plus hydroxychloroquine 4

ivermectin 27

ivermectin plus doxycycline 3

leronlimab

lopinavir / ritonavir plus ribavirin

lopinavir/ritonavir 9

Lopinavir/ritonavir plus hydroxychloroquine 1

lopinavir/ritonavir plus interferon ß-1a 1

lopinavir/ritonavir, ribavirin and interferon beta-1b 1

molnupiravir 2

niclosamide 1

nirmatrelvir / ritonavir (Paxlovid) 1

nitazoxanide 4

opaganib

oseltamivir 1

oseltamivir plus chloroquin

remdesivir 11

ritonavir

sofosbuvir 2

sofosbuvir and daclatasvir 6

sofosbuvir and ledipasvir 2

tenofovir/emtricitabine 1

tranexamic acid

tranilast

triazavirin

umifenovir (arbidol) 5

zinc 3

control

prone positioning

Drugs for acid related disorders

bismuth

H2 blockers

famotidine 2

proton pump inhibitors (PPI) 6

miscellaneous

2-deoxy-D-glucose (2-DG)

acetylcysteine

alpha lipoic acid 1

Aspirin 1

aviptadil

BLD-2660 (calpain inhibitor)

calcium channel blocker

camostat mesilate 1

Cannabidiol 1

continuous positive airway pressure (CPAP)

cytokine adsorption

diammonium glycyrrhizinate

dipyridamol

honey

kinin-kallikrein inhibitors

natural killer (NK) cells

nicotin

nitric oxide (gas Inhalation or releasing solution)

ozonated autohemotherapy

povidone-iodine 1

PUL-042 inhalation solution

pyridostigmine 1

radiotherapy

Oral antidiabetic drugs

dapagliflozin 1

DPP-4 inhibitor

metformin

Renin-angiotensin-system-acting agents 7

angiotensin converting enzyme inhibitors (ACEIs)

angiotensin receptor blockers (ARBs) 3

losartan 1

angiotensin-(1-7)

discontinuation of ACEI/ARB 3

RAS blocker withdrawal

rhACE2

vaccines

BCG vaccination

DNA vaccine

bacTRL-Spike

Vitamins

vitamin C 4

zinc plus vitamin c 1

Vitamin D 7

Follow-us

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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