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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

tutorial video
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Our approach

darunavir/cobicistat plus chloroquine

adjuvant therapies

anticoagulant 2

anticoagulant, curative dose 3

anticoagulant, prophylactic dose 4

anticoagulation, intermediate prophylactic dose 1

heparin at therapeutic dose 3

hydrogen-oxygen nebulizer

hyperbaric oxygen

pulmonary rehabilitation

anti-inflammatoty and immuno-therapy

acalabrutinib 2

anti-inflammatory therapies 1

naproxen, ibuprofen

non-steroidal anti-inflammatory drugs 5

sodium aescinate

corticosteroids 7

dexamethasone 3

Hydrocortisone 4

inhaled corticosteroids 1

low-dose corticosteroids

methylprednisolone 5

Immunostimulants drugs

anti-PD-1 antibody

convalescent plasma treatment 21

immunoglobulin therapy

inactivated mycobacterium vaccine

high-dose IFN beta-1a 1

inhaled interferon

recombinant super-compound interferon rSIFN-co 1

SNG001 inhaled interferon beta 1

interferon / TFF2 1

peginterferon 2

neutralizing antibody

bamlanivimab monotherapy 2

bamlanivimab plus etesevimab 3

BRII-196 and BRII-198 (Brii Biosciences)

casirivimab and imdevimab (REGN-COV2) 1

regdanvimab (CT-P59 Celltrion) 1

VIR-7831 / GSK4182136 2

Immunosuppressants drugs

anti-interleukin-6

sarilumab azithromycin hydroxychloroquine

sarilumab high dose (400mg) 1

sarilumab low dose (200mg) 1

baricitinib plus remdesivir 1

Polyinosinic-Polycytidylic Acid

5-alpha-reductase inhibitors

antiviral and associated therapy

ASC09/ritonavir

baloxavir marboxil 1

chloroquine and derivatives

hydroxychloroquine 42

danoprevir / ritonavir

darunavir cobicistat 1

hydroxychloroquine plus macrolides 8

lopinavir / ritonavir plus ribavirin

lopinavir/ritonavir 6

lopinavir/ritonavir plus interferon ß-1a

lopinavir/ritonavir, ribavirin and interferon beta-1b 1

oseltamivir plus chloroquin

Renin-angiotensin-system-acting agents 7

angiotensin converting enzyme inhibitors (ACEIs)

angiotensin receptor blockers (ARBs) 2

angiotensin-(1-7)

discontinuation of ACEI/ARB 2

RAS blocker withdrawal

sofosbuvir and daclatasvir 3

sofosbuvir and ledipasvir 1

tranexamic acid

umifenovir (arbidol) 5

clarithromycine

prone positioning

alpha lipoic acid 1

BLD-2660 (calpain inhibitor)

camostat mesilate

continuous positive airway pressure (CPAP)

cytokine adsorption

diammonium glycyrrhizinate

DPP-4 inhibitor

kinin-kallikrein inhibitors

natural killer (NK) cells

nitric oxide (gas Inhalation or releasing solution)

ozonated autohemotherapy

povidone-iodine

proton pump inhibitors (PPI) 6

PUL-042 inhalation solution

BCG vaccination

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

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