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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19

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Our approach

adjuvant therapies

anticoagulant 2

anticoagulant, curative dose 5

anticoagulant, pre-admission 3

anticoagulant, prophylactic dose 4

anticoagulation, intermediate prophylactic dose 1

heparin at therapeutic dose 1

P2Y12 inhibitors

hydrogen-oxygen nebulizer

hyperbaric oxygen

pulmonary rehabilitation

respiratory support

anti-inflammatoty and immuno-therapy

anti-inflammatory therapies 1

clarithromycine 2

Colchicine plus rosuvastatin 1

naproxen, ibuprofen

non-steroidal anti-inflammatory drugs 8

sodium aescinate

corticosteroids 7

dexamethasone 5

Dexamethasone 12mg 1

Hydrocortisone 4

low-dose corticosteroids

methylprednisolone 6

Immunostimulants drugs

anti-PD-1 antibody

convalescent plasma treatment 47

Early convalescent plasma. 1

immunoglobulin therapy 4

inactivated mycobacterium vaccine

high-dose IFN beta-1a 1

inhaled interferon

pegylated interferon-α2b 2

recombinant super-compound interferon rSIFN-co 1

SNG001 inhaled interferon beta 3

interferon / TFF2 1

peginterferon 3

neutralizing antibody 1

amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences) 2

bamlanivimab monotherapy 3

bamlanivimab/etesevimab 4

Bebtelovimab (LY-CoV1404) 1

casirivimab/imdevimab (Ronapreve) 5

cilgavimab and tixagevimab (Evusheld) 2

equine polyclonal antibodies INM005 1

regdanvimab (Regkirona- CT-P59-Celltrion) 2

sotrovimab (Xevudy; VIR-7831) 2

Immunosuppressants drugs

anti-interleukin-6

sarilumab azithromycin hydroxychloroquine

sarilumab high dose (400mg) 1

sarilumab low dose (200mg) 1

complement inhibitors

janus kinase (JAK) inhibitor

inhaled corticosteroids

Kinase inhibitors

acalabrutinib 2

Polyinosinic-Polycytidylic Acid

5-alpha-reductase inhibitors

antiviral and associated therapy

ASC09/ritonavir

azithromycin 12

baloxavir marboxil 1

chloroquine and derivatives 1

hydroxychloroquine 47

danoprevir / ritonavir

darunavir cobicistat 1

darunavir/cobicistat plus chloroquine

Emtricitabine/tenofovir plus colchicine plus rosuvastatin 1

Ensitrelvir (XOCOVA) 1

favipiravir plus interferon 1

hydroxychloroquine plus macrolides 7

azithromycin plus hydroxychloroquine 4

ivermectin plus doxycycline 3

lopinavir / ritonavir plus ribavirin

lopinavir/ritonavir 9

Lopinavir/ritonavir plus hydroxychloroquine 1

lopinavir/ritonavir plus interferon ß-1a 1

lopinavir/ritonavir, ribavirin and interferon beta-1b 1

nirmatrelvir / ritonavir (Paxlovid) 2

oseltamivir plus chloroquin

sofosbuvir and daclatasvir 6

sofosbuvir and ledipasvir 2

tenofovir/emtricitabine 1

tranexamic acid

umifenovir (arbidol) 5

prone positioning

Drugs for acid related disorders

proton pump inhibitors (PPI) 6

2-deoxy-D-glucose (2-DG)

alpha lipoic acid 1

BLD-2660 (calpain inhibitor)

calcium channel blocker

camostat mesilate 1

continuous positive airway pressure (CPAP)

cytokine adsorption

diammonium glycyrrhizinate

kinin-kallikrein inhibitors

natural killer (NK) cells

nitric oxide (gas Inhalation or releasing solution)

ozonated autohemotherapy

povidone-iodine 1

PUL-042 inhalation solution

pyridostigmine 1

Oral antidiabetic drugs

dapagliflozin 1

DPP-4 inhibitor 4

Renin-angiotensin-system-acting agents 7

angiotensin converting enzyme inhibitors (ACEIs)

angiotensin receptor blockers (ARBs) 3

angiotensin-(1-7)

discontinuation of ACEI/ARB 3

RAS blocker withdrawal

BCG vaccination

zinc plus vitamin c 1

hight dose vitamin D 1

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

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