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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

PlasmAr , 2020   NCT04344535 6 days ago

convalescent plasma treatment vs. control - COVID-19 severe or critically low risk of bias

  • inconclusive results for: death; clinical improvement

meta-analysis

hydroxychloroquine vs. standard of care - COVID-19 prophylaxis some concern in risk of bias

  • inconclusive results for: death; PCR-confirmed, symptomatic Covid-19 disease; serious AE; any AE

meta-analysis

ORCHID , 2020   NCT04332991 3 weeks ago

hydroxychloroquine vs. placebo - COVID 19 hospitalized low risk of bias

  • inconclusive results for: deaths (28 days); COVID Outcomes Scale score at 14 d,; serious AE

meta-analysis

BACC Bay Tocilizumab Trial , 2020   NCT04356937 2 months ago

tocilizumab vs. placebo - COVID-19 severe or critically low risk of bias

  • inconclusive results for: death; mechanical ventilation or death; clinical improvement on ordinal scale; clinical worsening on ordinal scale

meta-analysis

CORIMUNO-19 , 2020   NCT04331808 2 months ago

tocilizumab vs. standard of care - COVID-19 mild to moderate some concern in risk of bias

  • inconclusive results for: death (day 28); WHO-CPS score greater than 5 at day 14; Mechanical Ventilation, or Death (day 14)

meta-analysis

RCT-TCZ-COVID-19 , 2020   NCT04346355 2 months ago

tocilizumab vs. standard of care - COVID-19 mild to moderate some concern in risk of bias

  • inconclusive results for: death before 30 days; clinical worsening 14 days

meta-analysis

SOLIDARITY (WHO study) HCQ , 2020   NCT04315948 2 months ago

hydroxychloroquine vs. standard of care - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: 28 days death (rate ratio); death or initiation of ventilation

meta-analysis

SOLIDARITY (remdesivir) , 2020   NCT04315948 2 months ago

remdesivir vs. control - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: in-hospital mortality; death or initiation of ventilation; initiation of ventilation

meta-analysis

SOLIDARITY (lopi/rito) , 2020   NCT04315948 2 months ago

lopinavir/ritonavir vs. standard of care - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: in-hospital death

meta-analysis

SOLIDARITY (interferon) , 2020   NCT04315948 2 months ago

interferon vs. control - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: In-hospital deaths; death or initiation of ventilation

meta-analysis

Follow-us

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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