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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of potential therapies for COVID19

  Summary of results of all meta-analysis  
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Our approach


adjuvant therapies

anticoagulant 2

Bivalirudin

colchicine 1

hydrogen-oxygen nebulizer

hyperbaric oxygen

nintedanib

pulmonary rehabilitation

thalidomide

vitamin C

anti-inflammatoty and immuno-therapy

acalabrutinib

anti-inflammatory therapies 1

IFX-1

naproxen, ibuprofen

non-steroidal anti-inflammatory drugs

sodium aescinate

Apilimod

corticosteroids 12

ciclesonide

dexamethasone 1

inhaled steroids

low-dose corticosteroids

imatinib

Immunostimulants drugs

anti-PD-1 antibody

CD24Fc

convalescent plasma treatment 11

immunoglobulin therapy

emapalumab

inactivated mycobacterium vaccine

Interleukin-2

rhG-CSF

vaccines

Immunosuppressants drugs

anakinra 1

baricitinib

eculizumab

interleukin-6 inhibitor

clazakizumab

sarilumab 3

sarilumab azithromycin hydroxychloroquine

sarilumab high dose (400mg) 1

sarilumab low dose (200mg) 1

siltuximab

tocilizumab 15

jakotinib

lenzilumab

ruxolitinib

tacrolimus

tetrandrine

leflunomide

pirfenidone

Polyinosinic-Polycytidylic Acid

sargramostim

thymosin

antiviral and associated therapy

ASC09/ritonavir

azithromycin 2

azvudine

baloxavir marboxil

bromhexine

carrimycin

chloroquine and derivatives 7

chloroquine 1

hydroxychloroquine 21

danoprevir / ritonavir

darunavir cobicistat

darunavir/cobicistat plus chloroquine

favipiravir 1

hydroxychloroquine plus macrolides 7

interferon

SNG001 inhaled interferon beta 1

ivermectin

leronlimab

lopinavir / ritonavir plus ribavirin

lopinavir/ritonavir 3

lopinavir/ritonavir plus interferon ß-1a

lopinavir/ritonavir, ribavirin and interferon beta-1b

meplazumab

oseltamivir plus chloroquin

remdesevir 5

Renin-angiotensin-system-acting agents 6

angiotensin receptor blockers (ARBs)

angiotensin-(1-7)

discontinuation of ACEI/ARB 1

RAS blocker withdrawal

rhACE2

ritonavir

tranexamic acid

triazavirin

umifenovir (arbidol) 1

control

prone positioning

miscellaneous

acetylcysteine

alpha lipoic acid 1

aviptadil

bevacizumab

bismuth

BLD-2660 (calpain inhibitor)

camostat mesilate

continuous positive airway pressure (CPAP)

cytokine adsorption

diammonium glycyrrhizinate

dipyridamol

enoxaparin

kinin-kallikrein inhibitors

levamisole

natural killer (NK) cells

nitric oxide (gas Inhalation or releasing solution)

ozonated autohemotherapy

pamrevlumab

proton pump inhibitors 1

PUL-042 inhalation solution

selinexor

stem cells

tradipitant

tranilast

Latest studies

hydroxychloroquine vs. placebo - COVID-19 prophylaxis low risk of bias

  • inconclusive results for: PCR positive or probable Covid-19; PCR confirmed Covid-19

meta-analysis

hydroxychloroquine vs. placebo - COVID-19 prophylaxis low risk of bias

  • inconclusive results for: PCR positive or probable Covid-19; PCR confirmed Covid-19

meta-analysis

PATCH PreP (Abella) , 2020   NCT04329923 yesterday

hydroxychloroquine vs. placebo - COVID-19 prophylaxis some concern in risk of bias

  • inconclusive results for: PCR confirmed infection rate

meta-analysis

Edalatifard , 2020   IRCT20200404046947N1 9 days ago

corticosteroids vs. control - COVID-19 severe or critically high risk of bias

  • suggested 71 % decrease in death but with a low degree of certainty due to high risk of bias

meta-analysis

PLACID , 2020   CTRI/2020/04/024775 3 weeks ago

convalescent plasma treatment vs. control - COVID 19 hospitalized high risk of bias

  • inconclusive results for: 28-day death

meta-analysis

ConPlas-19 , 2020   NCT04345523 4 weeks ago

convalescent plasma treatment vs. standard of care - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: time to improvement; overall survival

meta-analysis

COALITION II (Furtado) , 2020   NCT04321278 4 weeks ago

azithromycin vs. control - COVID-19 severe or critically some concern in risk of bias

  • inconclusive results for: Score on six-point ordinal scale at day 15; Death at 29 days

meta-analysis

COVACTA (Rosas) , 2020   NCT04320615 4 weeks ago

tocilizumab vs. placebo - COVID-19 severe or critically some concern in risk of bias

  • inconclusive results for: Clinical status at day 28; Mortality at day 28; Serious infections

meta-analysis

CAPE-COVID , 2020   NCT02517489 4 weeks ago

corticosteroids vs. placebo - COVID-19 severe or critically low risk of bias

  • inconclusive results for: death; nosocomial infections

meta-analysis

REMAP-CAP, fixed 7-day course , 2020   NCT02735707 4 weeks ago

corticosteroids vs. control - COVID-19 severe or critically some concern in risk of bias

  • inconclusive results for: WHO scale at day 14d; death

meta-analysis

Follow-us

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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