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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

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COLCOVID , 2021   NCT04328480 2 weeks ago

colchicine vs. standard of care - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: 28-d mortality; 28-d composite (new requirement of mechanical ventilation or death)

meta-analysis

PINETREE (GS-US-540-9012) , 2021   NCT04501952 4 weeks ago

remdesivir vs. placebo - COVID 19 outpatients low risk of bias

  • statistically conclusive 87 % decrease in Covid-19–related hospitalization or death from any cause by day 28
  • suggested 72 % decrease in Hospitalization for any cause by day 28
  • suggested 75 % decrease in Patients with serious adverse events
  • inconclusive results for: Death from any cause by day 28; Patients with adverse event leading to discontinuation of trial regimen; Patients with any adverse event

meta-analysis

EPIC-HR , 2021   NCT04960202 4 weeks ago

nirmatrelvir / ritonavir (Paxlovid) vs. placebo - COVID 19 outpatients NA risk of bias

  • statistically conclusive 90 % decrease in Hospitalization or death from any cause in patients treated within three days of symptom onset.
  • suggested 96 % decrease in Death at day 28

risk of bias not assessable

meta-analysis

LIVE-AIR (Temesgen) , 2021   NCT04351152 4 weeks ago

lenzilumab vs. placebo - COVID-19 mild to moderate some concern in risk of bias

  • statistically conclusive 35 % decrease in Death or ventilation (derived from survival without ventilation to day 28)
  • inconclusive results for: Mortality

meta-analysis

Holm K , 2021   NCT04600440 4 weeks ago

convalescent plasma treatment vs. standard of care - COVID 19 hospitalized some concern in risk of bias

  • inconclusive results for: All-cause mortality; Progression to ventilator treatment

meta-analysis

Conclusive (statistically conclusive): statistically demonstrated that is statistically significant with a strict control of overall risk of type 1 error, does not take into account the risk of bias; inconclusive: not nominally statistically significant; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error

Follow-us

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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