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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

Veiga , 2021   NCT04403685 3 days ago

tocilizumab vs. control - COVID-19 severe or critically some concern in risk of bias

  • safety concerns with a 2.7-fold increase in Mortality up to 28 days
  • inconclusive results for: mechanical ventilation or died at day 15

meta-analysis

RECOVERY (plasma) , 2021   NCT04381936 8 days ago

convalescent plasma treatment vs. control - COVID 19 hospitalized NA risk of bias

  • inconclusive results for: 28-day mortality

risk of bias not assessable

meta-analysis

Libster , 2020   NCT04479163 10 days ago

convalescent plasma treatment vs. placebo - COVID-19 mild to moderate low risk of bias

  • demonstrated 48 % decrease in severe respiratory disease
  • inconclusive results for: death from Covid-19; admission to intensive care unit

meta-analysis

REMAP-CAP tocilizumab , 2021   NCT02735707 2 weeks ago

tocilizumab vs. standard of care - COVID-19 severe or critically some concern in risk of bias

  • suggested 30 % decrease in in hospital deaths
  • demonstrated 64 % increase in Organ support-free days

meta-analysis

REMAP-CAP sarilumab , 2021   NCT02735707 2 weeks ago

sarilumab vs. standard of care - COVID-19 severe or critically some concern in risk of bias

  • demonstrated 76 % increase in Organ support-free days
  • inconclusive results for: In-hospital deaths

meta-analysis

ACTIV-3/TICO LY-CoV555 , 2020   NCT04501978 4 weeks ago

neutralizing antibody vs. placebo - COVID 19 hospitalized low risk of bias

  • inconclusive results for: deaths; clinical improvement at day 5; Time to Hospital Discharge; Time until Sustained Recovery

meta-analysis

Moderna/NIH phase 3 (study 301) , 2020   NCT04470427 5 weeks ago

Moderna COVID-19 vaccine vs. placebo - COVID-19 prophylaxis some concern in risk of bias

  • suggested 95 % decrease in laboratory-confirmed Covid-19 after 1 dose
  • suggested 93 % decrease in Symptomatic Covid-19, ITT
  • demonstrated 94 % decrease in laboratory-confirmed Covid-19
  • demonstrated 98 % decrease in severe cases of Covid-19 after 2 doses
  • inconclusive results for: death; any SAE; any AE (unsolicited); appendicitis; arthralgia, grade 3-4; fever, grade 3-4; hypersensitivity, all; grade 3 adenopathy; severe lymphadenopathy; Musculoskeletal and connective tissue disorders; mylgia, grade 3-4; any local reaction (2nd injection); grade 3-4 local adverse reaction; any systemic reaction (2nd injection); grade 3-4 systemic adverse reaction

meta-analysis

RECOVERY-AZI (Horby) , 2020   NCT04381936 2 months ago

azithromycin vs. standard of care - COVID 19 hospitalized some concern in risk of bias

    Preliminary findings based on a data cut on 30 November. Final results will be made available after the last patient has completed the 28-day follow-up period for the primary outcome on 25 December 2020

  • inconclusive results for: death (28d); invasive mechanical ventilation or death; discharged from hospital alive within 28 days; any major cardiac arrhytmia

meta-analysis

ACTT-2 (Kalil) , 2020   NCT04401579 2 months ago

baricitinib plus remdesivir vs. remdesivir - COVID 19 hospitalized low risk of bias

  • demonstrated 16 % increase in time to recovery
  • suggested 31 % decrease in Death or progression to invasive mechanical ventilation
  • suggested 50 % decrease in serious or nonserious adverse events of new infection
  • inconclusive results for: death at 28 days; improvement in clinical status at day 15

meta-analysis

Lenze , 2020   NCT04342663 2 months ago

fluvoxamine vs. placebo - COVID 19 outpatients some concern in risk of bias

  • demonstrated 93 % decrease in Clinical deterioration
  • inconclusive results for: serious AE; any AE

meta-analysis

Demonstrated: statistically demonstrated that is statistically significant with a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error

Follow-us

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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