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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

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Treament Trials   auto
deathsclinical improvementdeath or ventilation
11 / 22 0.91 [0.82; 1.01], 8 RCTs, I2=38%
inconclusive result
1.04 [0.67; 1.62], 1 RCT, I2=0%
inconclusive result
0.92 [0.84; 1.00], 2 RCTs, I2=0%
inconclusive result
6 / 9 0.83 [0.63; 1.09], 6 RCTs, I2=26%
inconclusive result
1.30 [1.15; 1.46], 4 RCTs, I2=0% conclusive
moderate degree of certainty
0.97 [0.85; 1.10], 1 RCT, I2=0%
inconclusive result
16 / 27 0.99 [0.93; 1.05], 13 RCTs, I2=0%
inconclusive result
1.03 [0.88; 1.21], 6 RCTs, I2=0%
inconclusive result
0.99 [0.92; 1.06], 3 RCTs, I2=43%
inconclusive result
2 0.59 [0.45; 0.78], 2 RCTs, I2=0%
high degree of certainty
1.16 [1.01; 1.33], 1 RCT, I2=0% conclusive
high degree of certainty
0.69 [0.50; 0.95], 1 RCT, I2=0%
high degree of certainty
1 0.80 [0.70; 0.91], 1 RCT, I2=0% conclusive
moderate degree of certainty
- 0.83 [0.75; 0.92], 1 RCT, I2=0%
moderate degree of certainty
10 / 13 0.65 [0.34; 1.24], 7 RCTs, I2=31%
inconclusive result
2.34 [1.35; 4.05], 2 RCTs, I2=0%
moderate degree of certainty
0.83 [0.35; 1.93], 2 RCTs, I2=46%
inconclusive result
12 / 26 0.86 [0.74; 1.01], 11 RCTs, I2=14%
safety concern
inconclusive result
1.26 [1.04; 1.52], 5 RCTs, I2=36% conclusive
moderate degree of certainty
0.79 [0.65; 0.95], 6 RCTs, I2=20% conclusive
moderate degree of certainty
3 / 6 1.09 [0.56; 2.12], 2 RCTs, I2=0%
inconclusive result
1.03 [0.75; 1.41], 1 RCT, I2=0%
inconclusive result
-
3 / 4 1.06 [0.83; 1.37], 3 RCTs, I2=39%
inconclusive result
0.83 [0.67; 1.03], 1 RCT, I2=0%
inconclusive result
0.82 [0.63; 1.07], 1 RCT, I2=0%
inconclusive result
1 1.09 [0.78; 1.53], 1 RCT, I2=0%
inconclusive result
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Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

121
treatments
  523
studies with results
  1204
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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