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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19  

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button bars forest bayes pooled summary
Treament Trials   auto
deathsclinical improvementdeath or ventilation
19 0.92 [0.81; 1.04], 9 RCTs, I2=42%
inconclusive result		 1.32 [0.95; 1.84], 2 RCTs, I2=0%
inconclusive result		 0.92 [0.84; 1.00], 2 RCTs, I2=0%
inconclusive result
5 0.64 [0.45; 0.91], 4 RCTs, I2=0%
moderate degree of certainty		 1.30 [1.15; 1.46], 4 RCTs, I2=0% conclusive
moderate degree of certainty		 0.97 [0.85; 1.10], 1 RCT, I2=0%
inconclusive result
35 1.09 [0.98; 1.21], 11 RCTs, I2=0%
inconclusive result		 1.02 [0.73; 1.42], 1 RCT, I2=0%
inconclusive result		 1.13 [1.03; 1.24], 4 RCTs, I2=0%
statistically significant harm
20 0.88 [0.69; 1.12], 7 RCTs, I2=12%
inconclusive result		 1.04 [0.80; 1.36], 4 RCTs, I2=0%
inconclusive result		 0.99 [0.93; 1.05], 1 RCT, I2=0%
inconclusive result
12 0.60 [0.29; 1.24], 6 RCTs, I2=43%
inconclusive result		 2.32 [1.07; 5.04], 1 RCT, I2=0%
moderate degree of certainty		 0.83 [0.35; 1.93], 2 RCTs, I2=46%
inconclusive result
22 0.89 [0.74; 1.07], 8 RCTs, I2=19%
safety concern
inconclusive result		 1.26 [1.04; 1.52], 5 RCTs, I2=36% conclusive
moderate degree of certainty		 0.81 [0.66; 1.01], 5 RCTs, I2=18%
inconclusive result
6 0.79 [0.46; 1.36], 3 RCTs, I2=16%
inconclusive result		 1.31 [0.78; 2.21], 2 RCTs, I2=72%
inconclusive result		-
4 0.31 [0.04; 2.15], 2 RCTs, I2=0%
inconclusive result		--
2 1.05 [0.82; 1.35], 1 RCT, I2=0%
inconclusive result		 0.87 [0.70; 1.08], 1 RCT, I2=0%
inconclusive result		-
1 1.09 [0.78; 1.53], 1 RCT, I2=0%
inconclusive result		--

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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