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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

tutorial video
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Our approach
     
Treament Trials
deathsclinical improvementdeath or ventilation
corticosteroids 14 0.85 [0.78; 0.94], 6 RCTs, I2=0% demonstrated
moderate degree of certainty
1.16 [0.84; 1.60], 2 RCTs, I2=0%
inconclusive result
0.71 [0.37; 1.35], 1 RCT, I2=0%
inconclusive result
remdesivir 6 0.91 [0.79; 1.05], 5 RCTs, I2=0%
inconclusive result
1.32 [1.16; 1.50], 4 RCTs, I2=0% demonstrated
moderate degree of certainty
0.97 [0.85; 1.10], 1 RCT, I2=0%
inconclusive result
hydroxychloroquine 37 1.10 [0.99; 1.22], 14 RCTs, I2=0%
inconclusive result
1.13 [0.86; 1.48], 2 RCTs, I2=1%
inconclusive result
1.14 [1.03; 1.25], 3 RCTs, I2=0%
statistically significant harm
convalescent plasma treatment 12 0.77 [0.46; 1.30], 4 RCTs, I2=0%
inconclusive result
0.99 [0.73; 1.33], 3 RCTs, I2=5%
inconclusive result
-
interferon 6 1.16 [0.96; 1.40], 1 RCT, I2=0%
inconclusive result
- 1.05 [0.90; 1.23], 1 RCT, I2=0%
inconclusive result
anti-interleukin-6 22 1.07 [0.70; 1.63], 4 RCTs, I2=0%
inconclusive result
1.12 [0.95; 1.33], 3 RCTs, I2=0%
inconclusive result
0.62 [0.42; 0.93], 3 RCTs, I2=0% demonstrated
moderate degree of certainty
lopinavir/ritonavir 5 1.01 [0.91; 1.13], 6 RCTs, I2=0%
inconclusive result
1.72 [0.98; 3.01], 3 RCTs, I2=64%
inconclusive result
-
anakinra 2 ---
colchicine 3 0.21 [0.02; 1.97], 1 RCT, I2=0%
inconclusive result
--
anticoagulant 2 ---
Vitamin D 5 0.12 [0.01; 2.79], 1 RCT, I2=0%
inconclusive result
--

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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