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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19

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Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Interactive explorer of NMA results

8RECOVERY dexamethasone, 2020 Metcovid, 2020 CODEX (Tomazini), 2020 CAPE-COVID, 2020 Tang X, 2020 Steroids-SARI, 2020 DEXA-COVID19, 2020 Jamaati, 20211Ranjbar, 20216CAP-China (Wang et al.), 2020 NIH NIAID ACTT-1, 2020 SOLIDARITY (remdesivir), 2020 GS-US-540-5774, 10 days, 2020 GS-US-540-5774, 5 days, 2020 Mahajan, 202116RECOVERY, 2020 COVID-PEP Severity (Skipper), 2020 Abd-Elsalam, 2020 TEACH, 2020 HYCOVID, 2020 Chen, 2020 NO COVID-19 (Lyngbakken), 2020 SOLIDARITY (WHO study) HCQ, 2020 Coalition Covid-19 Brazil I (Cavalcanti)-Hydroxychloroquine, 2020 BCN PEP-CoV-2-Study 2 (Mitja et al. Clin Infect Dis), 2020 ORCHID, 2020 PATCH Cohort 1 (Amaravadi), 2021 HYDRA (Hernandez-Cardenas), 2021 Gonzalez_HCQ, 2020 Coalition Covid-19 Brazil I (Cavalcanti)-Hydroxychloroquine, 2020 FACCT Trial, 20211Galan, 202114Li, 2020 ConCOVID (Gharbharan et al.), 2020 PlasmAr, 2020 Libster, 2020 RECOVERY (plasma), 2021 O’Donnell, 2021 AlQahtani, 2020 CAPSID, 2021 REMAP-CAP plasma, 2021 CONCOR-1, 2021 Sekine (PLACOVID), 2021 C3PO, 2020 Kirenga, 2021 ConPlas-19, 20208SOLIDARITY (interferon), 2020 Rahmani, 2020 Synairgen SG016, 2020 Darazam (COVIFERON Interferon beta-1a), 2021 Darazam (COVIFERON Interferon beta-1b), 2021 Fu, 2020 Pandit, 2021 Shashi Bhushan, 20212Li, 2021 Darazam, 202120CORIMUNO-TOCI-1 (Group 1), 2020 BACC Bay Tocilizumab Trial, 2020 EMPACTA, 2020 REMAP-CAP tocilizumab, 2021 RCT-TCZ-COVID-19, 2021 Veiga, 2021 RECOVERY, 2021 Soin AS (COVINTOC), 2021 COVACTA (Rosas), 2020 Talaschian, 2021 Rutgers, 2021 NCT04412772 (ARCHITECTS), 0 NCT04330638 (COV-AID), 0 NCT04577534 (COVIDSTORM), 0 EU-CTR2020-001375-32 (PreToVid), 0 EU-CTR2020-001748-24 (ImmCoVA), 0 NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0 NCT04434717 (COVITOZ-1 single dose plus two doses), 0 CORIMUNO-TOCI-ICU (Group 2), 2020 Rosas (REMDACTA), 20212Lescure (Sarilumab 400mg), 2021 Lescure (Sarilumab 200mg), 20215Salehzadeh, 2020 GRECCO-19, 2020 COLCORONA, 2021 Horby, 2021 PRINCIPLE (COLCHICINE), 20217Hashim A, 2020 NCT04523831 (Mahmud), 2020 Lopez-Medina, 2021 Kirti, 2021 Gonzalez_IVER, 2020 Krolewiecki, 2020 IVERCORCOVID19 (Vallejos), 2020colchicine vs. control 1.00 [0.92; 1.09]1.00 [0.92;1.09]colchicine vs. control 1.00 [0.92; 1.09]colchicine vs. convalescent plasma treatment 1.02 [0.92; 1.13]1.02 [0.92;1.13]colchicine vs. convalescent plasma treatment 1.02 [0.92; 1.13]colchicine vs. corticosteroids 1.06 [0.96; 1.16]1.06 [0.96;1.16]colchicine vs. corticosteroids 1.06 [0.96; 1.16]colchicine vs. hydroxychloroquine 0.94 [0.83; 1.08]0.94 [0.83;1.08]colchicine vs. hydroxychloroquine 0.94 [0.83; 1.08]colchicine vs. interferon 0.92 [0.75; 1.12]0.92 [0.75;1.12]colchicine vs. interferon 0.92 [0.75; 1.12]colchicine vs. ivermectin 1.22 [0.76; 1.96]1.22 [0.76;1.96]colchicine vs. ivermectin 1.22 [0.76; 1.96]colchicine vs. remdesivir 1.12 [0.95; 1.33]1.12 [0.95;1.33]colchicine vs. remdesivir 1.12 [0.95; 1.33]colchicine vs. sarilumab 0.92 [0.47; 1.79]0.92 [0.47;1.79]colchicine vs. sarilumab 0.92 [0.47; 1.79]colchicine vs. tocilizumab tocilizumab better 1.19 [1.05; 1.34]1.19 [1.05;1.34]colchicine vs. tocilizumab tocilizumab better 1.19 [1.05; 1.34]control vs. colchicine 1.00 [0.92; 1.08]1.00 [0.92;1.08]control vs. colchicine 1.00 [0.92; 1.08]control vs. convalescent plasma treatment 1.01 [0.95; 1.08]1.01 [0.95;1.08]control vs. convalescent plasma treatment 1.01 [0.95; 1.08]control vs. corticosteroids corticosteroids better 1.05 [1.01; 1.10]1.05 [1.01;1.10]control vs. corticosteroids corticosteroids better 1.05 [1.01; 1.10]control vs. hydroxychloroquine 0.94 [0.85; 1.04]0.94 [0.85;1.04]control vs. hydroxychloroquine 0.94 [0.85; 1.04]control vs. interferon 0.91 [0.76; 1.09]0.91 [0.76;1.09]control vs. interferon 0.91 [0.76; 1.09]control vs. ivermectin 1.21 [0.76; 1.94]1.21 [0.76;1.94]control vs. ivermectin 1.21 [0.76; 1.94]control vs. remdesivir 1.12 [0.97; 1.29]1.12 [0.97;1.29]control vs. remdesivir 1.12 [0.97; 1.29]control vs. sarilumab 0.91 [0.47; 1.77]0.91 [0.47;1.77]control vs. sarilumab 0.91 [0.47; 1.77]control vs. tocilizumab tocilizumab better 1.18 [1.08; 1.29]1.18 [1.08;1.29]control vs. tocilizumab tocilizumab better 1.18 [1.08; 1.29]convalescent plasma treatment vs. colchicine 0.98 [0.89; 1.09]0.98 [0.89;1.09]convalescent plasma treatment vs. colchicine 0.98 [0.89; 1.09]convalescent plasma treatment vs. control 0.99 [0.93; 1.05]0.99 [0.93;1.05]convalescent plasma treatment vs. control 0.99 [0.93; 1.05]convalescent plasma treatment vs. corticosteroids 1.04 [0.96; 1.12]1.04 [0.96;1.12]convalescent plasma treatment vs. corticosteroids 1.04 [0.96; 1.12]convalescent plasma treatment vs. hydroxychloroquine 0.93 [0.82; 1.04]0.93 [0.82;1.04]convalescent plasma treatment vs. hydroxychloroquine 0.93 [0.82; 1.04]convalescent plasma treatment vs. interferon 0.90 [0.74; 1.09]0.90 [0.74;1.09]convalescent plasma treatment vs. interferon 0.90 [0.74; 1.09]convalescent plasma treatment vs. ivermectin 1.20 [0.75; 1.92]1.20 [0.75;1.92]convalescent plasma treatment vs. ivermectin 1.20 [0.75; 1.92]convalescent plasma treatment vs. remdesivir 1.11 [0.95; 1.29]1.11 [0.95;1.29]convalescent plasma treatment vs. remdesivir 1.11 [0.95; 1.29]convalescent plasma treatment vs. sarilumab 0.90 [0.46; 1.76]0.90 [0.46;1.76]convalescent plasma treatment vs. sarilumab 0.90 [0.46; 1.76]convalescent plasma treatment vs. tocilizumab tocilizumab better 1.17 [1.05; 1.30]1.17 [1.05;1.30]convalescent plasma treatment vs. tocilizumab tocilizumab better 1.17 [1.05; 1.30]corticosteroids vs. colchicine 0.95 [0.86; 1.04]0.95 [0.86;1.04]corticosteroids vs. colchicine 0.95 [0.86; 1.04]corticosteroids vs. control corticosteroids better 0.95 [0.91; 0.99]0.95 [0.91;0.99]corticosteroids vs. control corticosteroids better 0.95 [0.91; 0.99]corticosteroids vs. convalescent plasma treatment 0.96 [0.89; 1.04]0.96 [0.89;1.04]corticosteroids vs. convalescent plasma treatment 0.96 [0.89; 1.04]corticosteroids vs. hydroxychloroquine corticosteroids better 0.89 [0.80; 1.00]0.89 [0.80;1.00]corticosteroids vs. hydroxychloroquine corticosteroids better 0.89 [0.80; 1.00]corticosteroids vs. interferon 0.87 [0.72; 1.04]0.87 [0.72;1.04]corticosteroids vs. interferon 0.87 [0.72; 1.04]corticosteroids vs. ivermectin 1.15 [0.72; 1.85]1.15 [0.72;1.85]corticosteroids vs. ivermectin 1.15 [0.72; 1.85]corticosteroids vs. remdesivir 1.07 [0.92; 1.24]1.07 [0.92;1.24]corticosteroids vs. remdesivir 1.07 [0.92; 1.24]corticosteroids vs. sarilumab 0.87 [0.45; 1.69]0.87 [0.45;1.69]corticosteroids vs. sarilumab 0.87 [0.45; 1.69]corticosteroids vs. tocilizumab tocilizumab better 1.12 [1.02; 1.24]1.12 [1.02;1.24]corticosteroids vs. tocilizumab tocilizumab better 1.12 [1.02; 1.24]hydroxychloroquine vs. colchicine 1.06 [0.93; 1.21]1.06 [0.93;1.21]hydroxychloroquine vs. colchicine 1.06 [0.93; 1.21]hydroxychloroquine vs. control 1.06 [0.96; 1.18]1.06 [0.96;1.18]hydroxychloroquine vs. control 1.06 [0.96; 1.18]hydroxychloroquine vs. convalescent plasma treatment 1.08 [0.96; 1.21]1.08 [0.96;1.21]hydroxychloroquine vs. convalescent plasma treatment 1.08 [0.96; 1.21]hydroxychloroquine vs. corticosteroids corticosteroids better 1.12 [1.00; 1.25]1.12 [1.00;1.25]hydroxychloroquine vs. corticosteroids corticosteroids better 1.12 [1.00; 1.25]hydroxychloroquine vs. interferon 0.97 [0.79; 1.19]0.97 [0.79;1.19]hydroxychloroquine vs. interferon 0.97 [0.79; 1.19]hydroxychloroquine vs. ivermectin 1.29 [0.81; 2.06]1.29 [0.81;2.06]hydroxychloroquine vs. ivermectin 1.29 [0.81; 2.06]hydroxychloroquine vs. remdesivir remdesivir better 1.19 [1.00; 1.42]1.19 [1.00;1.42]hydroxychloroquine vs. remdesivir remdesivir better 1.19 [1.00; 1.42]hydroxychloroquine vs. sarilumab 0.97 [0.50; 1.90]0.97 [0.50;1.90]hydroxychloroquine vs. sarilumab 0.97 [0.50; 1.90]hydroxychloroquine vs. tocilizumab tocilizumab better 1.26 [1.10; 1.44]1.26 [1.10;1.44]hydroxychloroquine vs. tocilizumab tocilizumab better 1.26 [1.10; 1.44]interferon vs. colchicine 1.09 [0.90; 1.33]1.09 [0.90;1.33]interferon vs. colchicine 1.09 [0.90; 1.33]interferon vs. control 1.10 [0.92; 1.31]1.10 [0.92;1.31]interferon vs. control 1.10 [0.92; 1.31]interferon vs. convalescent plasma treatment 1.11 [0.92; 1.34]1.11 [0.92;1.34]interferon vs. convalescent plasma treatment 1.11 [0.92; 1.34]interferon vs. corticosteroids 1.15 [0.96; 1.39]1.15 [0.96;1.39]interferon vs. corticosteroids 1.15 [0.96; 1.39]interferon vs. hydroxychloroquine 1.03 [0.84; 1.27]1.03 [0.84;1.27]interferon vs. hydroxychloroquine 1.03 [0.84; 1.27]interferon vs. ivermectin 1.33 [0.80; 2.20]1.33 [0.80;2.20]interferon vs. ivermectin 1.33 [0.80; 2.20]interferon vs. remdesivir 1.23 [0.98; 1.55]1.23 [0.98;1.55]interferon vs. remdesivir 1.23 [0.98; 1.55]interferon vs. sarilumab 1.00 [0.50; 1.99]1.00 [0.50;1.99]interferon vs. sarilumab 1.00 [0.50; 1.99]interferon vs. tocilizumab tocilizumab better 1.30 [1.06; 1.58]1.30 [1.06;1.58]interferon vs. tocilizumab tocilizumab better 1.30 [1.06; 1.58]ivermectin vs. colchicine 0.82 [0.51; 1.32]0.82 [0.51;1.32]ivermectin vs. colchicine 0.82 [0.51; 1.32]ivermectin vs. control 0.82 [0.52; 1.32]0.82 [0.52;1.32]ivermectin vs. control 0.82 [0.52; 1.32]ivermectin vs. convalescent plasma treatment 0.84 [0.52; 1.34]0.84 [0.52;1.34]ivermectin vs. convalescent plasma treatment 0.84 [0.52; 1.34]ivermectin vs. corticosteroids 0.87 [0.54; 1.39]0.87 [0.54;1.39]ivermectin vs. corticosteroids 0.87 [0.54; 1.39]ivermectin vs. hydroxychloroquine 0.77 [0.49; 1.24]0.77 [0.49;1.24]ivermectin vs. hydroxychloroquine 0.77 [0.49; 1.24]ivermectin vs. interferon 0.75 [0.46; 1.24]0.75 [0.46;1.24]ivermectin vs. interferon 0.75 [0.46; 1.24]ivermectin vs. remdesivir 0.92 [0.57; 1.51]0.92 [0.57;1.51]ivermectin vs. remdesivir 0.92 [0.57; 1.51]ivermectin vs. sarilumab 0.75 [0.33; 1.70]0.75 [0.33;1.70]ivermectin vs. sarilumab 0.75 [0.33; 1.70]ivermectin vs. tocilizumab 0.97 [0.60; 1.57]0.97 [0.60;1.57]ivermectin vs. tocilizumab 0.97 [0.60; 1.57]remdesivir vs. colchicine 0.89 [0.75; 1.05]0.89 [0.75;1.05]remdesivir vs. colchicine 0.89 [0.75; 1.05]remdesivir vs. control 0.89 [0.77; 1.03]0.89 [0.77;1.03]remdesivir vs. control 0.89 [0.77; 1.03]remdesivir vs. convalescent plasma treatment 0.90 [0.77; 1.06]0.90 [0.77;1.06]remdesivir vs. convalescent plasma treatment 0.90 [0.77; 1.06]remdesivir vs. corticosteroids 0.94 [0.81; 1.09]0.94 [0.81;1.09]remdesivir vs. corticosteroids 0.94 [0.81; 1.09]remdesivir vs. hydroxychloroquine remdesivir better 0.84 [0.70; 1.00]0.84 [0.70;1.00]remdesivir vs. hydroxychloroquine remdesivir better 0.84 [0.70; 1.00]remdesivir vs. interferon 0.81 [0.65; 1.02]0.81 [0.65;1.02]remdesivir vs. interferon 0.81 [0.65; 1.02]remdesivir vs. ivermectin 1.08 [0.66; 1.77]1.08 [0.66;1.77]remdesivir vs. ivermectin 1.08 [0.66; 1.77]remdesivir vs. sarilumab 0.82 [0.41; 1.61]0.82 [0.41;1.61]remdesivir vs. sarilumab 0.82 [0.41; 1.61]remdesivir vs. tocilizumab 1.05 [0.89; 1.25]1.05 [0.89;1.25]remdesivir vs. tocilizumab 1.05 [0.89; 1.25]sarilumab vs. colchicine 1.09 [0.56; 2.13]1.09 [0.56;2.13]sarilumab vs. colchicine 1.09 [0.56; 2.13]sarilumab vs. control 1.09 [0.56; 2.12]1.09 [0.56;2.12]sarilumab vs. control 1.09 [0.56; 2.12]sarilumab vs. convalescent plasma treatment 1.11 [0.57; 2.16]1.11 [0.57;2.16]sarilumab vs. convalescent plasma treatment 1.11 [0.57; 2.16]sarilumab vs. corticosteroids 1.15 [0.59; 2.24]1.15 [0.59;2.24]sarilumab vs. corticosteroids 1.15 [0.59; 2.24]sarilumab vs. hydroxychloroquine 1.03 [0.53; 2.01]1.03 [0.53;2.01]sarilumab vs. hydroxychloroquine 1.03 [0.53; 2.01]sarilumab vs. interferon 1.00 [0.50; 1.98]1.00 [0.50;1.98]sarilumab vs. interferon 1.00 [0.50; 1.98]sarilumab vs. ivermectin 1.33 [0.59; 2.99]1.33 [0.59;2.99]sarilumab vs. ivermectin 1.33 [0.59; 2.99]sarilumab vs. remdesivir 1.23 [0.62; 2.42]1.23 [0.62;2.42]sarilumab vs. remdesivir 1.23 [0.62; 2.42]sarilumab vs. tocilizumab 1.29 [0.66; 2.52]1.29 [0.66;2.52]sarilumab vs. tocilizumab 1.29 [0.66; 2.52]tocilizumab vs. colchicine tocilizumab better 0.84 [0.75; 0.95]0.84 [0.75;0.95]tocilizumab vs. colchicine tocilizumab better 0.84 [0.75; 0.95]tocilizumab vs. control tocilizumab better 0.85 [0.77; 0.93]0.85 [0.77;0.93]tocilizumab vs. control tocilizumab better 0.85 [0.77; 0.93]tocilizumab vs. convalescent plasma treatment tocilizumab better 0.86 [0.77; 0.96]0.86 [0.77;0.96]tocilizumab vs. convalescent plasma treatment tocilizumab better 0.86 [0.77; 0.96]tocilizumab vs. corticosteroids tocilizumab better 0.89 [0.81; 0.98]0.89 [0.81;0.98]tocilizumab vs. corticosteroids tocilizumab better 0.89 [0.81; 0.98]tocilizumab vs. hydroxychloroquine tocilizumab better 0.80 [0.70; 0.91]0.80 [0.70;0.91]tocilizumab vs. hydroxychloroquine tocilizumab better 0.80 [0.70; 0.91]tocilizumab vs. interferon tocilizumab better 0.77 [0.63; 0.94]0.77 [0.63;0.94]tocilizumab vs. interferon tocilizumab better 0.77 [0.63; 0.94]tocilizumab vs. ivermectin 1.03 [0.64; 1.65]1.03 [0.64;1.65]tocilizumab vs. ivermectin 1.03 [0.64; 1.65]tocilizumab vs. remdesivir 0.95 [0.80; 1.12]0.95 [0.80;1.12]tocilizumab vs. remdesivir 0.95 [0.80; 1.12]tocilizumab vs. sarilumab 0.77 [0.40; 1.51]0.77 [0.40;1.51]tocilizumab vs. sarilumab 0.77 [0.40; 1.51]corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferontocilizumab sarilumabcolchicineivermectincontroldirect evidencenetwork meta-analysis

Click on treatment name to display related network evidence

T vs. C corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferontocilizumab sarilumabcolchicineivermectincontrol
corticosteroids---1.07
0.92; 1.24
0.89
0.80; 1.00
0.96
0.89; 1.04
0.87
0.72; 1.04
1.12
1.02; 1.24
0.87
0.45; 1.69
0.95
0.86; 1.04
1.15
0.72; 1.85
0.95
0.91; 0.99
remdesivir0.94
0.81; 1.09
---0.84
0.70; 1.00
0.90
0.77; 1.06
0.81
0.65; 1.02
1.05
0.89; 1.25
0.82
0.41; 1.61
0.89
0.75; 1.05
1.08
0.66; 1.77
0.89
0.77; 1.03
hydroxychloroquine1.12
1.00; 1.25
1.19
1.00; 1.42
---1.08
0.96; 1.21
0.97
0.79; 1.19
1.26
1.10; 1.44
0.97
0.50; 1.90
1.06
0.93; 1.21
1.29
0.81; 2.06
1.06
0.96; 1.18
convalescent plasma treatment1.04
0.96; 1.12
1.11
0.95; 1.29
0.93
0.82; 1.04
---0.90
0.74; 1.09
1.17
1.05; 1.30
0.90
0.46; 1.76
0.98
0.89; 1.09
1.20
0.75; 1.92
0.99
0.93; 1.05
interferon1.15
0.96; 1.39
1.23
0.98; 1.55
1.03
0.84; 1.27
1.11
0.92; 1.34
---1.30
1.06; 1.58
1.00
0.50; 1.99
1.09
0.90; 1.33
1.33
0.80; 2.20
1.10
0.92; 1.31
tocilizumab 0.89
0.81; 0.98
0.95
0.80; 1.12
0.80
0.70; 0.91
0.86
0.77; 0.96
0.77
0.63; 0.94
---0.77
0.40; 1.51
0.84
0.75; 0.95
1.03
0.64; 1.65
0.85
0.77; 0.93
sarilumab1.15
0.59; 2.24
1.23
0.62; 2.42
1.03
0.53; 2.01
1.11
0.57; 2.16
1.00
0.50; 1.98
1.29
0.66; 2.52
---1.09
0.56; 2.13
1.33
0.59; 2.99
1.09
0.56; 2.12
colchicine1.06
0.96; 1.16
1.12
0.95; 1.33
0.94
0.83; 1.08
1.02
0.92; 1.13
0.92
0.75; 1.12
1.19
1.05; 1.34
0.92
0.47; 1.79
---1.22
0.76; 1.96
1.00
0.92; 1.09
ivermectin0.87
0.54; 1.39
0.92
0.57; 1.51
0.77
0.49; 1.24
0.84
0.52; 1.34
0.75
0.46; 1.24
0.97
0.60; 1.57
0.75
0.33; 1.70
0.82
0.51; 1.32
---0.82
0.52; 1.32
control1.05
1.01; 1.10
1.12
0.97; 1.29
0.94
0.85; 1.04
1.01
0.95; 1.08
0.91
0.76; 1.09
1.18
1.08; 1.29
0.91
0.47; 1.77
1.00
0.92; 1.08
1.21
0.76; 1.94
---

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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