metaOBS - - Real World Evidence KB

Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament	Trials	Summary Endpoints
Treament	Trials	Demonstrated or suggested benefit	Inconclusive results	Uncertain results	Safety results
Immunosuppressants drugs	38	demonstrated 44 % increase in clinical improvement suggested 90 % increase in clinical improvement (14-day)	inconclusive results for: deaths (time to event analysis only); clinical deterioration; clinical improvement (21-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; viral clearance (time to event analysis only); ICU admission; recovery; related AE (TRAE); serious adverse events; superinfection; acute kidney injury ; adverse events; elevated liver enzymes; Myocardial infarction ; venous thromboembolism	suggested 7 % decrease in death or transfer to ICU but the degree if certainty is unassessable suggested 5.5-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable suggested 84 % decrease in arrhythmia but the degree if certainty is unassessable	12 % decrease in death D28 with safety concern 19 % decrease in deaths with safety concern
Immunostimulants drugs	27	suggested 26 % decrease in deaths demonstrated 20 % increase in clinical improvement (time to event analysis only) suggested 38 % decrease in ICU admission	inconclusive results for: 14-days deaths; death D28; death or transfer to ICU; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); hospital discharge; mechanical ventilation; mechanical ventilation (time to event analysis only); radiologic improvement (14-day); viral clearance ; viral clearance by day 14; off oxygenation; serious adverse events; superinfection; adverse events	-	-
corticosteroids	16	none	inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; serious adverse events; superinfection	suggested 4.9-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable	-
anti-inflammatory therapies	4	none	inconclusive results for: death D28; deaths; clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); hospital discharge; mechanical ventilation; serious adverse events; adverse events	suggested 10.3-fold increase in clinical improvement but the degree if certainty is unassessable suggested 10.3-fold increase in clinical improvement (14-day) but the degree if certainty is unassessable suggested 6.7-fold increase in clinical improvement (7-day) but the degree if certainty is unassessable	-
Apilimod	0	-	-	-	-
inhaled corticosteroids	0	-	-	-	-
Kinase inhibitors	0	-	-	-	-
leflunomide	0	-	-	-	-
meplazumab	0	-	-	-	-
pirfenidone	0	-	-	-	-
Polyinosinic-Polycytidylic Acid	0	-	-	-	-
sargramostim	0	-	-	-	-
statins	0	-	-	-	-
thymosin	0	-	-	-	-