Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). metaEvidence.org method

Treament Trials  
clinical improvementclinical worseningdeathsPCR-negative conversion
chloroquine and derivatives22 1.43 [0.88; 2.34], 7 studies, I2=69%
inconclusive result
1.01 [0.81; 1.25], 4 studies, I2=0%
inconclusive result
0.96 [0.71; 1.29], 9 studies, I2=73%
safety concern
inconclusive result
1.34 [0.60; 2.96], 4 studies, I2=72%
inconclusive result
Renin-angiotensin-system-acting agents12- 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
0.91 [0.70; 1.17], 6 studies, I2=50%
inconclusive result
-
hydroxychloroquine plus macrolides4- 0.30 [0.22; 0.41], 1 study, I2=0%
very low degree of certainty
1.07 [0.69; 1.66], 4 studies, I2=62%
inconclusive result
-
lopinavir/ritonavir3 1.23 [0.99; 1.53], 3 studies, I2=0%
inconclusive result
3.69 [0.37; 36.57], 1 study, I2=0%
inconclusive result
1.00 [0.80; 1.25], 2 studies, I2=14%
inconclusive result
0.84 [0.59; 1.19], 2 studies, I2=0%
inconclusive result
remdesevir2 1.30 [1.12; 1.51], 2 studies, I2=0%
moderate degree of certainty
- 0.77 [0.54; 1.09], 2 studies, I2=0%
inconclusive result
-
azithromycin1-- 0.56 [0.26; 1.21], 1 study, I2=0%
inconclusive result
-
favipiravir 1 1.48 [0.88; 2.48], 1 study, I2=0%
inconclusive result
---
umifenovir (arbidol)1 1.04 [0.54; 2.02], 2 studies, I2=72%
inconclusive result
0.86 [0.06; 11.36], 1 study, I2=0%
inconclusive result
- 0.97 [0.65; 1.46], 2 studies, I2=0%
inconclusive result
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
fluvoxamine0----
interferon0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
lopinavir/ritonavir, ribavirin and interferon beta-1b0----
meplazumab0----
nitazoxanide0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----

metaEvidence.org method