Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
death D28 | 0.67 [0.34, 1.33] | | < 1 | | 0% | 4 studies (4/-) | 87.4 % | some concern | not evaluable | moderate | crucial | - |
deaths | 0.77 [0.51, 1.18] | | < 1 | | 0% | 12 studies (12/-) | 88.6 % | some concern | low | moderate | crucial | - |
deaths (time to event analysis only) | 0.64 [0.28, 1.48] | | < 1 | | 0% | 3 studies (3/-) | 85.1 % | some concern | not evaluable | moderate | crucial | - |
clinical deterioration | 0.88 [0.55, 1.40] | | < 1 | | 33% | 6 studies (6/-) | 71.1 % | some concern | not evaluable | moderate | important | - |
clinical improvement | 1.33 [1.04, 1.71] | | > 1 | | 54% | 9 studies (9/-) | 98.9 % | some concern | not evaluable | moderate | important | - |
clinical improvement (14-day) | 1.19 [0.97, 1.46] | | > 1 | | 28% | 7 studies (7/-) | 95.0 % | some concern | not evaluable | moderate | important | - |
clinical improvement (21-day) | 2.09 [0.04, 119.96] | | > 1 | | 0% | 1 study (1/-) | 63.7 % | NA | not evaluable | | important | - |
clinical improvement (28-day) | 1.47 [1.06, 2.04] | | > 1 | | 59% | 4 studies (4/-) | 99.0 % | some concern | not evaluable | moderate | important | - |
clinical improvement (7-day) | 1.36 [1.05, 1.76] | | > 1 | | 51% | 6 studies (6/-) | 99.1 % | some concern | not evaluable | moderate | important | - |
clinical improvement (time to event analysis only) | 1.27 [1.03, 1.56] | | > 1 | | 60% | 6 studies (6/-) | 98.7 % | some concern | not evaluable | moderate | important | - |
hospital discharge | 1.26 [0.70, 2.25] | | > 1 | | 72% | 3 studies (3/-) | 77.9 % | some concern | not evaluable | moderate | important | - |
mechanical ventilation | 0.65 [0.25, 1.69] | | < 1 | | 56% | 6 studies (6/-) | 80.9 % | some concern | serious | moderate | important | - |
mechanical ventilation (time to event analysis only) | 0.06 [0.01, 0.83] | | < 1 | | 0% | 1 study (1/-) | 98.2 % | NA | not evaluable | | important | - |
radiologic improvement (14-day) | 1.17 [0.42, 3.26] | | > 1 | | 16% | 3 studies (3/-) | 62.1 % | some concern | not evaluable | moderate | important | - |
radiologic improvement (7-day) | 0.09 [0.01, 0.78] | | > 1 | | 0% | 2 studies (2/-) | 1.5 % | some concern | not evaluable | moderate | important | - |
viral clearance | 1.77 [1.15, 2.72] | | > 1 | | 51% | 7 studies (7/-) | 99.5 % | some concern | not evaluable | moderate | important | - |
viral clearance (time to event analysis only) | 1.32 [1.03, 1.69] | | > 1 | | 0% | 2 studies (2/-) | 98.6 % | some concern | not evaluable | moderate | important | - |
viral clearance by day 14 | 0.99 [0.93, 1.06] | | > 1 | | 0% | 5 studies (5/-) | 41.7 % | some concern | not evaluable | moderate | important | - |
viral clearance by day 7 | 1.20 [0.70, 2.04] | | > 1 | | 45% | 5 studies (5/-) | 74.8 % | some concern | not evaluable | moderate | important | - |
ICU admission | 1.32 [0.79, 2.21] | | < 1 | | 0% | 2 studies (2/-) | 14.5 % | some concern | not evaluable | moderate | non important | - |
recovery | 1.15 [0.99, 1.33] | | > 1 | | 0% | 2 studies (2/-) | 96.4 % | some concern | not evaluable | moderate | non important | - |
safety endpoints 00 |
serious adverse events | 0.74 [0.45, 1.20] | | < 1 | | 0% | 9 studies (9/-) | 88.9 % | some concern | serious | moderate | important | - |
acute kidney injury | 1.18 [0.44, 3.18] | | < 1 | | 0% | 1 study (1/-) | 37.2 % | NA | not evaluable | | non important | - |
adverse events | 1.62 [1.20, 2.18] | | < 1 | | 55% | 10 studies (10/-) | 0.1 % | some concern | low | moderate | non important | - |
arrhythmia | 2.24 [0.23, 21.69] | | < 1 | | 0% | 1 study (1/-) | 24.5 % | NA | not evaluable | | non important | - |
elevated liver enzymes | 3.48 [1.40, 8.64] | | < 1 | | 0% | 1 study (1/-) | 0.4 % | NA | not evaluable | | non important | - |
long QT | 9.79 [1.27, 75.50] | | < 1 | | 0% | 1 study (1/-) | 1.5 % | NA | not evaluable | | non important | - |
renal impairment | 1.35 [0.47, 3.86] | | < 1 | | 0% | 1 study (1/-) | 28.8 % | NA | not evaluable | | non important | - |
AE of interest endpoints 00 |
Thromboembolic events | 0.89 [0.31, 2.55] | | < 1 | | 0% | 1 study (1/-) | 58.6 % | NA | not evaluable | | non important | - |