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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

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Treament Trials
Statistically conclusive or suggested result Inconclusive results Uncertain results Safety results
7 / 16

suggested 4.9-fold increase in radiologic improvement (14-day)

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; serious adverse events; superinfection--
1 noneinconclusive results for: deaths; clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); AE leading to drug discontinuation; serious adverse events; deep vein thrombosis; elevated liver enzymes; hyperbilirubinemia; pulmonary embolism; renal impairment--
9 / 17 noneinconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); mechanical ventilation; off oxygenation; serious adverse events; adverse events--
0- - - -
0- - - -
4 / 5

statistically conclusive 66 % increase in clinical improvement (time to event analysis only)

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); hospital discharge; mechanical ventilation; ICU admission; off oxygenation; superinfection--
7 / 17

statistically conclusive 44 % increase in clinical improvement

suggested 52 % decrease in ICU admission

inconclusive results for: deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; recovery; serious adverse events; superinfection; adverse events-

4 % increase in death D28 with safety concern

6 % decrease in deaths with safety concern

3 / 6 noneinconclusive results for: deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); serious adverse events; adverse events--
1 noneinconclusive results for: deaths; clinical improvement; Major thrombotic events or death; Major bleeding--
1 noneinconclusive results for: deaths; Major bleeding; Thromboembolic events--

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

129
treatments
  576
studies with results
  1273
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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