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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

Member of the meta|Evidence galaxy

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Treament Trials
Statistically conclusive or suggested result Inconclusive results Uncertain results Safety results
0- - - -
7 / 16 noneinconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; serious adverse events; superinfection

suggested 4.9-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable

-
1 noneinconclusive results for: deaths; clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); AE leading to drug discontinuation; serious adverse events; deep vein thrombosis; elevated liver enzymes; hyperbilirubinemia; pulmonary embolism; renal impairment--
11 / 18 noneinconclusive results for: 14-days deaths; death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); mechanical ventilation; mechanical ventilation (time to event analysis only); viral clearance ; viral clearance by day 14; ICU admission; off oxygenation; serious adverse events; adverse events--
1 / 2 noneinconclusive results for: death or transfer to ICU; clinical improvement (14-day); clinical improvement (28-day); ICU admission; recovery; acute kidney injury ; arrhythmia; elevated liver enzymes; Myocardial infarction ; venous thromboembolism

suggested 46 % decrease in death D28 but the degree if certainty is unassessable

suggested 46 % decrease in deaths but the degree if certainty is unassessable

suggested 2.9-fold increase in clinical improvement but the degree if certainty is unassessable

-
1 / 2 noneinconclusive results for: deaths--
0- - - -
0- - - -
4 / 5

statistically conclusive 66 % increase in clinical improvement (time to event analysis only)

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); hospital discharge; mechanical ventilation; ICU admission; off oxygenation; superinfection--
8 / 18

statistically conclusive 44 % increase in clinical improvement

inconclusive results for: deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; recovery; serious adverse events; superinfection; adverse events

suggested 52 % decrease in ICU admission but the degree if certainty is unassessable

4 % increase in death D28 with safety concern

6 % decrease in deaths with safety concern

3 / 6 noneinconclusive results for: deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); serious adverse events; adverse events--
2 noneinconclusive results for: deaths; clinical improvement; Major thrombotic events or death; Major bleeding--
1 noneinconclusive results for: deaths; Major bleeding; Thromboembolic events--

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

149
treatments
  718
studies with results
  1743
studies screend
  1629
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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