All patients
age >= 55 yr age >= 60 yr age >= 65 yr autoimmune disease corticosteroids: no corticosteroids: yes critical disease invasive ventilation no oxygen needed non invasive oxygen omicron variant BA.1 (B.1.1.529) severe disease solid organ transplant recipients subjects at risk
anti-inflammatoty and immuno-therapy in COVID 19 outpatients - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results PRINCIPLE (COLCHICINE), 2021 0.42 [0.01; 12.75]
0.42 [0.01 ; 12.75 ] PRINCIPLE (COLCHICINE), 2021 1 0% 289 NA not evaluable deathsdetailed results PRINCIPLE (COLCHICINE), 2021 0.42 [0.01; 12.75]
0.42 [0.01 ; 12.75 ] PRINCIPLE (COLCHICINE), 2021 1 0% 289 NA not evaluable hospitalization or deathdetailed results PRINCIPLE, 2021 0.81 [0.58; 1.13]
PRINCIPLE (COLCHICINE), 2021 1.29 [0.36; 4.67]
0.83 [0.60 ; 1.16 ] PRINCIPLE, 2021, PRINCIPLE (COLCHICINE), 2021 2 0% 1,949 moderate not evaluable clinical improvementdetailed results PRINCIPLE, 2021 1.21 [1.08; 1.36]
1.21 [1.08 ; 1.36 ] PRINCIPLE, 2021 1 0% 1,779 NA not evaluable hospitalizationdetailed results PRINCIPLE (COLCHICINE), 2021 1.73 [0.43; 7.07]
1.73 [0.43 ; 7.07 ] PRINCIPLE (COLCHICINE), 2021 1 0% 289 NA not evaluable mechanical ventilationdetailed results PRINCIPLE, 2021 1.02 [0.45; 2.33]
1.02 [0.45 ; 2.33 ] PRINCIPLE, 2021 1 0% 1,503 NA not evaluable ICU admissiondetailed results PRINCIPLE, 2021 0.54 [0.24; 1.21]
0.54 [0.24 ; 1.21 ] PRINCIPLE, 2021 1 0% 1,491 NA not evaluable recoverydetailed results PRINCIPLE, 2021 1.21 [1.08; 1.36]
PRINCIPLE (COLCHICINE), 2021 0.92 [0.72; 1.17]
1.08 [0.83 ; 1.40 ] PRINCIPLE, 2021, PRINCIPLE (COLCHICINE), 2021 2 75% 4,072 moderate not evaluable 0.2 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-05 23:18 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 97
- treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525
- roots T: 290