published meta-analysis   sensitivity analysis   studies

anti-inflammatoty and immuno-therapy in COVID-19 severe or critically - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsAman, 2021 0.51 [0.27; 0.96] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.02 [0.62; 1.68] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] O’Donnell, 2021 0.47 [0.21; 1.06] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Shi, 2020 0.53 [0.01; 27.55] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] 0.77[0.60; 0.98]Aman, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Kalil (ACTT-3), 2021, O’Donnell, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 20211011%3,214moderatelow death or transfer to ICUdetailed resultsLopardo, 2021 0.65 [0.35; 1.22] 0.65[0.35; 1.22]Lopardo, 202110%241NAnot evaluable deathsdetailed resultsAman, 2021 0.51 [0.27; 0.96] CAPE-COVID, 2020 0.45 [0.20; 1.02] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.16 [0.73; 1.84] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Lescure (Sarilumab 200mg), 2021 1.23 [0.49; 3.12] Lescure (Sarilumab 400mg), 2021 0.97 [0.38; 2.50] Lopardo, 2021 0.57 [0.24; 1.37] O’Donnell, 2021 0.47 [0.21; 1.06] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Shi, 2020 0.53 [0.01; 27.55] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] 0.77[0.62; 0.97]Aman, 2021, CAPE-COVID, 2020, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Lopardo, 2021, O’Donnell, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 20211414%4,119moderatelow deaths (time to event analysis only)detailed resultsCOVACTA (Rosas), 2020 1.16 [0.73; 1.84] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] 1.04[0.80; 1.35]COVACTA (Rosas), 2020, Kalil (ACTT-3), 2021, PlasmAr, 2020, Rosas (REMDACTA), 202140%2,395moderatenot evaluable clinical improvementdetailed resultsCOV-BARRIER (critically ill), 2022 2.87 [1.12; 7.36] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] Kalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Lopardo, 2021 1.61 [0.75; 3.49] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 0.81 [0.50; 1.31] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] 1.08[0.94; 1.24]COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lopardo, 2021, O’Donnell, 2021, PlasmAr, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021916%2,577moderateserious clinical improvement (14-day)detailed resultsCOV-BARRIER (critically ill), 2022 1.97 [0.95; 4.09] Kalil (ACTT-3), 2021 1.01 [0.79; 1.29] 1.29[0.69; 2.41]COV-BARRIER (critically ill), 2022, Kalil (ACTT-3), 2021266%1,070moderatenot evaluable clinical improvement (28-day)detailed resultsCOV-BARRIER (critically ill), 2022 1.82 [0.87; 3.81] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] O’Donnell, 2021 1.38 [0.73; 2.61] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] 1.34[1.00; 1.81]COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, O’Donnell, 2021, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202150%787moderateserious clinical improvement (time to event analysis only)detailed resultsKalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Lescure (Sarilumab 400mg), 2021 1.14 [0.84; 1.54] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 1.00 [0.76; 1.32] 1.03[0.93; 1.14]Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, O’Donnell, 2021, PlasmAr, 202050%2,032moderatenot evaluable death or ventilationdetailed resultsCAPE-COVID, 2020 0.71 [0.37; 1.35] Rosas (REMDACTA), 2021 0.98 [0.72; 1.34] 0.92[0.70; 1.22]CAPE-COVID, 2020, Rosas (REMDACTA), 202120%798moderatenot evaluable hospital dischargedetailed resultsCAPE-COVID, 2020 1.67 [0.87; 3.19] Rosas (REMDACTA), 2021 0.97 [0.79; 1.20] 1.16[0.70; 1.92]CAPE-COVID, 2020, Rosas (REMDACTA), 2021259%798moderatenot evaluable mechanical ventilationdetailed resultsCAPE-COVID, 2020 0.95 [0.44; 2.04] COVACTA (Rosas), 2020 0.67 [0.39; 1.14] O’Donnell, 2021 1.50 [0.47; 4.82] PlasmAr, 2020 0.86 [0.39; 1.93] Singh (TD-0903 1mg), 2021 0.09 [0.00; 2.48] Singh (TD-0903 3mg), 2021 0.08 [0.00; 2.07] 0.79[0.53; 1.16]CAPE-COVID, 2020, COVACTA (Rosas), 2020, O’Donnell, 2021, PlasmAr, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202167%1,003lownot evaluable ICU admissiondetailed resultsCOVACTA (Rosas), 2020 0.48 [0.25; 0.94] Lopardo, 2021 0.67 [0.35; 1.28] 0.57[0.36; 0.91]COVACTA (Rosas), 2020, Lopardo, 202120%432moderatenot evaluable recoverydetailed resultsCOV-BARRIER (critically ill), 2022 1.57 [0.77; 3.20] 1.57[0.77; 3.20]COV-BARRIER (critically ill), 202210%101NAnot evaluable related AE (TRAE)detailed resultsSingh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 0.38 [0.01; 13.93] 1.26[0.14; 11.07]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202120%25moderatenot evaluable serious adverse eventsdetailed resultsCOVACTA (Rosas), 2020 0.81 [0.54; 1.22] Lescure (Sarilumab 200mg), 2021 1.15 [0.62; 2.12] Lescure (Sarilumab 400mg), 2021 1.38 [0.76; 2.51] O’Donnell, 2021 0.64 [0.35; 1.17] PlasmAr, 2020 1.40 [0.78; 2.51] Rosas (REMDACTA), 2021 0.83 [0.59; 1.18] Shi, 2020 1.08 [0.04; 32.96] 0.94[0.76; 1.15]COVACTA (Rosas), 2020, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, O’Donnell, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Shi, 202075%2,234moderatenot evaluable superinfectiondetailed resultsCAPE-COVID, 2020 0.81 [0.49; 1.34] 0.81[0.49; 1.34]CAPE-COVID, 202010%149NAnot evaluable adverse eventsdetailed resultsCOVACTA (Rosas), 2020 0.87 [0.52; 1.45] Lescure (Sarilumab 200mg), 2021 0.97 [0.56; 1.69] Lescure (Sarilumab 400mg), 2021 1.31 [0.76; 2.27] Rosas (REMDACTA), 2021 1.32 [0.92; 1.89] Shi, 2020 0.88 [0.38; 2.03] Singh (TD-0903 1mg), 2021 0.45 [0.01; 16.71] Singh (TD-0903 3mg), 2021 0.04 [0.00; 1.01] 1.08[0.83; 1.39]COVACTA (Rosas), 2020, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Rosas (REMDACTA), 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021713%1,707moderateserious0.25.01.0relative treatment effectwww.metaEvidence.org2024-05-03 22:45 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 91 - treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525 - roots T: 290