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janus kinase (JAK) inhibitor in COVID-19 severe or critically - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsCOV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] 0.52[0.30; 0.89]COV-BARRIER (critically ill), 2022, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202130%126lownot evaluable deathsdetailed resultsCOV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] 0.52[0.30; 0.89]COV-BARRIER (critically ill), 2022, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202130%126lownot evaluable clinical improvementdetailed resultsCOV-BARRIER (critically ill), 2022 2.87 [1.12; 7.36] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] 2.84[1.22; 6.63]COV-BARRIER (critically ill), 2022, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202130%126lownot evaluable clinical improvement (14-day)detailed resultsCOV-BARRIER (critically ill), 2022 1.97 [0.95; 4.09] 1.97[0.95; 4.09]COV-BARRIER (critically ill), 202210%101NAnot evaluable clinical improvement (28-day)detailed resultsCOV-BARRIER (critically ill), 2022 1.82 [0.87; 3.81] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] 1.92[0.96; 3.82]COV-BARRIER (critically ill), 2022, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202130%126lownot evaluable mechanical ventilationdetailed resultsSingh (TD-0903 1mg), 2021 0.09 [0.00; 2.48] Singh (TD-0903 3mg), 2021 0.08 [0.00; 2.07] 0.08[0.01; 0.86]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202120%25moderatenot evaluable recoverydetailed resultsCOV-BARRIER (critically ill), 2022 1.57 [0.77; 3.20] 1.57[0.77; 3.20]COV-BARRIER (critically ill), 202210%101NAnot evaluable related AE (TRAE)detailed resultsSingh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 0.38 [0.01; 13.93] 1.26[0.14; 11.07]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202120%25moderatenot evaluable adverse eventsdetailed resultsSingh (TD-0903 1mg), 2021 0.45 [0.01; 16.71] Singh (TD-0903 3mg), 2021 0.04 [0.00; 1.01] 0.12[0.01; 1.37]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202122%25moderatenot evaluable0.05.01.0relative treatment effectwww.metaEvidence.org2024-04-27 10:13 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 91 - treatments: 1046,727,818,606,954,964,962,963,1045 - roots T: 290