published meta-analysis   sensitivity analysis   studies

tocilizumab in COVID-19 severe or critically - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsCORIMUNO-TOCI-ICU (Group 2), 2020 0.64 [0.23; 1.80] Talaschian, 2021 1.56 [0.34; 7.13] Veiga, 2021 2.70 [0.92; 7.92] 1.36[0.54; 3.41]CORIMUNO-TOCI-ICU (Group 2), 2020, Talaschian, 2021, Veiga, 2021345%257moderatenot evaluable deathsdetailed resultsCORIMUNO-TOCI-1 (Group 1), 2020 0.92 [0.31; 2.71] CORIMUNO-TOCI-ICU (Group 2), 2020 0.64 [0.23; 1.80] REMAP-CAP (tocilizumab), 2021 0.70 [0.51; 0.95] Talaschian, 2021 1.25 [0.30; 5.14] Veiga, 2021 2.70 [0.92; 7.92] 0.93[0.57; 1.50]CORIMUNO-TOCI-1 (Group 1), 2020, CORIMUNO-TOCI-ICU (Group 2), 2020, REMAP-CAP (tocilizumab), 2021, Talaschian, 2021, Veiga, 2021536%1,138moderatenot evaluable deaths (time to event analysis only)detailed resultsTalaschian, 2021 1.25 [0.30; 5.14] 1.25[0.30; 5.14]Talaschian, 202110%40NAnot evaluable clinical deteriorationdetailed resultsCORIMUNO-TOCI-1 (Group 1), 2020 0.56 [0.26; 1.20] 0.56[0.26; 1.20]CORIMUNO-TOCI-1 (Group 1), 202010%130NAnot evaluable clinical improvementdetailed resultsREMAP-CAP (tocilizumab), 2021 1.64 [1.25; 2.15] 1.64[1.25; 2.15]REMAP-CAP (tocilizumab), 202110%755NAnot evaluable death or ventilationdetailed resultsCORIMUNO-TOCI-1 (Group 1), 2020 0.56 [0.24; 1.31] Veiga, 2021 1.54 [0.65; 3.63] 0.93[0.35; 2.49]CORIMUNO-TOCI-1 (Group 1), 2020, Veiga, 2021263%260moderatenot evaluable recoverydetailed resultsTalaschian, 2021 0.64 [0.14; 2.92] 0.64[0.14; 2.92]Talaschian, 202110%36NAnot evaluable serious adverse eventsdetailed resultsTalaschian, 2021 7.93 [0.37; 171.38] Veiga, 2021 1.66 [0.60; 4.59] 1.94[0.74; 5.09]Talaschian, 2021, Veiga, 202120%165moderatenot evaluable adverse eventsdetailed resultsVeiga, 2021 1.65 [0.81; 3.37] 1.65[0.81; 3.37]Veiga, 202110%129NAnot evaluable0.25.01.0relative treatment effectwww.metaEvidence.org2024-05-03 01:21 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 91 - treatments: 395 - roots T: 290