All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID 19 hospitalized - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results COALITION II Covid-19 Brazil (Furtado), 2020 1.08 [0.79; 1.47]
RECOVERY (AZI, Horby), 2020 0.97 [0.87; 1.08]
0.98 [0.89 ; 1.08 ] COALITION II Covid-19 Brazil (Furtado), 2020, RECOVERY (AZI, Horby), 2020 2 0% 8,161 moderate not evaluable deathsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 0.43 [0.13; 1.44]
COALITION II Covid-19 Brazil (Furtado), 2020 1.08 [0.79; 1.47]
HAHPS, 2020 7.00 [0.80; 60.90]
RECOVERY (AZI, Horby), 2020 0.97 [0.87; 1.08]
Sekhavati, 2020 0.49 [0.02; 14.80]
0.99 [0.79 ; 1.26 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020, HAHPS, 2020, RECOVERY (AZI, Horby), 2020, Sekhavati, 2020 5 28% 8,688 moderate not evaluable deaths (time to event analysis only)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 1.08 [0.79; 1.47]
RECOVERY (AZI, Horby), 2020 0.97 [0.87; 1.08]
0.98 [0.89 ; 1.08 ] COALITION II Covid-19 Brazil (Furtado), 2020, RECOVERY (AZI, Horby), 2020 2 0% 8,161 moderate not evaluable clinical deteriorationdetailed results HAHPS, 2020 1.07 [0.63; 1.82]
1.07 [0.63 ; 1.82 ] HAHPS, 2020 1 0% NA not evaluable clinical improvementdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 0.82 [0.47; 1.43]
COALITION II Covid-19 Brazil (Furtado), 2020 0.74 [0.51; 1.07]
0.76 [0.56 ; 1.04 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020 2 0% 728 moderate not evaluable clinical improvement (14-day)detailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 0.82 [0.47; 1.43]
COALITION II Covid-19 Brazil (Furtado), 2020 0.74 [0.51; 1.07]
0.76 [0.56 ; 1.04 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020 2 0% 728 moderate not evaluable clinical improvement (28-day)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 0.70 [0.47; 1.04]
0.70 [0.47 ; 1.04 ] COALITION II Covid-19 Brazil (Furtado), 2020 1 0% 397 NA not evaluable clinical improvement (7-day)detailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 0.89 [0.59; 1.35]
COALITION II Covid-19 Brazil (Furtado), 2020 0.94 [0.63; 1.40]
0.92 [0.69 ; 1.22 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020 2 0% 728 moderate not evaluable death or ventilationdetailed results RECOVERY (AZI, Horby), 2020 0.95 [0.87; 1.03]
0.95 [0.87 ; 1.03 ] RECOVERY (AZI, Horby), 2020 1 0% 7,764 NA not evaluable hospital dischargedetailed results HAHPS, 2020 0.91 [0.54; 1.54]
RECOVERY (AZI, Horby), 2020 1.04 [0.98; 1.10]
1.04 [0.98 ; 1.10 ] HAHPS, 2020, RECOVERY (AZI, Horby), 2020 2 0% 7,849 moderate not evaluable mechanical ventilationdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 1.54 [0.70; 3.37]
RECOVERY (AZI, Horby), 2020 0.92 [0.79; 1.07]
Sekhavati, 2020 0.16 [0.01; 3.19]
1.00 [0.62 ; 1.61 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, RECOVERY (AZI, Horby), 2020, Sekhavati, 2020 3 32% 8,206 moderate not evaluable radiologic improvement (14-day)detailed results Rashad A (AZI vs SoC), 2021 1.64 [0.94; 2.88]
1.64 [0.94 ; 2.88 ] Rashad A (AZI vs SoC), 2021 1 0% 206 NA not evaluable ICU admissiondetailed results Sekhavati, 2020 0.25 [0.05; 1.28]
0.25 [0.05 ; 1.28 ] Sekhavati, 2020 1 0% 111 NA not evaluable related SAE (TRSAE)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 1.24 [0.50; 3.11]
1.24 [0.50 ; 3.11 ] COALITION II Covid-19 Brazil (Furtado), 2020 1 0% 439 NA not evaluable serious adverse eventsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 1.02 [0.20; 5.10]
COALITION II Covid-19 Brazil (Furtado), 2020 1.20 [0.82; 1.77]
1.19 [0.82 ; 1.73 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020 2 0% 877 moderate not evaluable adverse eventsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 1.21 [0.82; 1.78]
1.21 [0.82 ; 1.78 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 1 0% 438 NA not evaluable arrhythmiadetailed results RECOVERY (AZI, Horby), 2020 0.90 [0.71; 1.15]
Sekhavati, 2020 0.98 [0.02; 50.38]
0.90 [0.71 ; 1.14 ] RECOVERY (AZI, Horby), 2020, Sekhavati, 2020 2 0% 7,874 moderate not evaluable long QTdetailed results COALITION II Covid-19 Brazil (Furtado), 2020 0.90 [0.56; 1.43]
0.90 [0.56 ; 1.43 ] COALITION II Covid-19 Brazil (Furtado), 2020 1 0% 439 NA not evaluable renal impairmentdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 1.35 [0.47; 3.86]
COALITION II Covid-19 Brazil (Furtado), 2020 1.44 [0.99; 2.11]
1.43 [1.00 ; 2.05 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020, COALITION II Covid-19 Brazil (Furtado), 2020 2 0% 770 moderate not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-08 12:17 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 95,94,90,91
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290
