All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID-19 prophylaxis (excluding children) - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias 6 months symptomatic COVIDdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.09 [0.07; 0.11]
0.09 [0.07 ; 0.11 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 46,077 NA not evaluable confirmed Covid-19, from 1st dosedetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.18 [0.13; 0.25]
0.18 [0.13 ; 0.25 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 42,572 NA not evaluable deathsdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.50 [0.09; 2.73]
0.50 [0.09 ; 2.73 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable vaccine efficacy from randomization (ITT)detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.18 [0.13; 0.25]
0.18 [0.13 ; 0.25 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 42,572 NA not evaluable confirmed COVID (any severity)detailed results C4591031- first boost, 2021 0.05 [0.02; 0.13]
0.05 [0.02 ; 0.13 ] C4591031- first boost, 2021 1 0% 10,125 NA not evaluable symptomatic Covid-19detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.05 [0.02; 0.10]
0.05 [0.02 ; 0.10 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 36,523 NA not evaluable 6 months severe COVID-19detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.03 [0.00; 0.46]
0.03 [0.00 ; 0.46 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% NA not evaluable severe COVID-19 (FDA definition)detailed results C4591031- first boost, 2021 0.25 [0.01; 5.50]
0.25 [0.01 ; 5.50 ] C4591031- first boost, 2021 1 0% 10,125 NA not evaluable severe COVID-19 occurrencedetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.25 [0.01; 5.62]
C4591031- first boost, 2021 0.25 [0.01; 5.50]
0.25 [0.03 ; 2.24 ] BNT162b2 phase 3 (C4591001, Polack), 2020, C4591031- first boost, 2021 2 0% 52,698 low not evaluable vaccine efficacy after dose 1 (and before dose 2)detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.48 [0.32; 0.71]
0.48 [0.32 ; 0.71 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,355 NA not evaluable related AE (TRAE)detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 4.91 [4.58; 5.26]
4.91 [4.58 ; 5.26 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable related SAE (TRSAE)detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 8.00 [0.42; 151.43]
8.00 [0.42 ; 151.43 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable serious adverse eventsdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 1.14 [0.88; 1.47]
1.14 [0.88 ; 1.47 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable adverse eventsdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 2.62 [2.49; 2.76]
2.62 [2.49 ; 2.76 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable arrhythmiadetailed results C4591031- first boost, 2021 1.99 [0.07; 59.22]
1.99 [0.07 ; 59.22 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable hypertensiondetailed results C4591031- first boost, 2021 0.50 [0.02; 14.80]
0.50 [0.02 ; 14.80 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable life-threatening SAEdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 0.91 [0.51; 1.65]
0.91 [0.51 ; 1.65 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable Myocardial infarction detailed results C4591031- first boost, 2021 0.74 [0.17; 3.33]
0.74 [0.17 ; 3.33 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable pulmonary embolismdetailed results C4591031- first boost, 2021 0.17 [0.01; 3.30]
0.17 [0.01 ; 3.30 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable severe adverse eventsdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 1.74 [1.41; 2.14]
1.74 [1.41 ; 2.14 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable stroke (non-specific, hemorrhagic, and ischemic)detailed results C4591031- first boost, 2021 0.99 [0.06; 15.88]
0.99 [0.06 ; 15.88 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable cerebral venous sinus thrombosis (CVST)detailed results C4591031- first boost, 2021 0.50 [0.02; 14.80]
0.50 [0.02 ; 14.80 ] C4591031- first boost, 2021 1 0% 10,075 NA not evaluable appendicitisdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 2.00 [0.60; 6.65]
C4591031- first boost, 2021 3.97 [0.18; 88.14]
2.19 [0.71 ; 6.70 ] BNT162b2 phase 3 (C4591001, Polack), 2020, C4591031- first boost, 2021 2 0% 53,523 moderate not evaluable Bell's palsydetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 7.99 [0.42; 151.24]
7.99 [0.42 ; 151.24 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 37,586 NA not evaluable hypersensitivity, all termsdetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 2.17 [0.82; 5.71]
2.17 [0.82 ; 5.71 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,252 NA not evaluable immediate allergic reactiondetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 1.00 [0.02; 50.42]
1.00 [0.02 ; 50.42 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 43,448 NA not evaluable lymphadenopathy, anydetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 10.69 [4.63; 24.69]
10.69 [4.63 ; 24.69 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 37,586 NA not evaluable musculoskeletal and connective tissue disorders, anydetailed results BNT162b2 phase 3 (C4591001, Polack), 2020 3.65 [3.26; 4.09]
3.65 [3.26 ; 4.09 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 37,586 NA not evaluable local adverse reaction, any, dose 1detailed results Out of scale BNT162b2 phase 3 (C4591001, Polack), 2020 24.90 [22.13; 28.03]
24.90 [22.13 ; 28.03 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 8,183 NA not evaluable local adverse reaction, any, dose 2detailed results Out of scale BNT162b2 phase 3 (C4591001, Polack), 2020 23.04 [20.30; 26.15]
23.04 [20.30 ; 26.15 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 7,507 NA not evaluable systemic adverse reaction, any, dose 1detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 1.63 [1.50; 1.78]
1.63 [1.50 ; 1.78 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 8,183 NA not evaluable systemic adverse reaction, any, dose 2detailed results BNT162b2 phase 3 (C4591001, Polack), 2020 4.55 [4.13; 5.01]
4.55 [4.13 ; 5.01 ] BNT162b2 phase 3 (C4591001, Polack), 2020 1 0% 7,507 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-04 14:26 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 89
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290
