All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID 19 hospitalized - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results RAPID (Sholzberg), 2021 0.22 [0.07; 0.67]
0.22 [0.07 ; 0.67 ] RAPID (Sholzberg), 2021 1 0% 465 NA not evaluable death or transfer to ICUdetailed results RAPID (Sholzberg), 2021 0.70 [0.44; 1.12]
0.70 [0.44 ; 1.12 ] RAPID (Sholzberg), 2021 1 0% 465 NA not evaluable deathsdetailed results ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021 0.88 [0.64; 1.20]
COALIZAO ACTION, 2021 1.55 [0.90; 2.70]
COVID-PACT, 2022 0.91 [0.56; 1.48]
INSPIRATION, 2021 1.09 [0.78; 1.53]
RAPID (Sholzberg), 2021 0.22 [0.07; 0.67]
REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 1.08 [0.85; 1.38]
0.99 [0.77 ; 1.26 ] ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021, COALIZAO ACTION, 2021, COVID-PACT, 2022, INSPIRATION, 2021, RAPID (Sholzberg), 2021, REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 6 54% 5,347 moderate not evaluable clinical deteriorationdetailed results COALIZAO ACTION, 2021 1.35 [0.85; 2.15]
RAPID (Sholzberg), 2021 0.69 [0.43; 1.10]
Ravichandran, 2021 0.02 [0.00; 0.36]
0.67 [0.25 ; 1.77 ] COALIZAO ACTION, 2021, RAPID (Sholzberg), 2021, Ravichandran, 2021 3 82% 1,290 moderate not evaluable clinical improvementdetailed results REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 0.83 [0.67; 1.03]
0.83 [0.67 ; 1.03 ] REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 1 0% 1,074 NA not evaluable clinical improvement (28-day)detailed results ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021 1.27 [1.03; 1.57]
1.27 [1.03 ; 1.57 ] ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021 1 0% 2,219 NA not evaluable death or ventilationdetailed results ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021 0.82 [0.63; 1.07]
RAPID (Sholzberg), 2021 0.59 [0.34; 1.02]
0.76 [0.58 ; 1.00 ] ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021, RAPID (Sholzberg), 2021 2 11% 2,696 moderate not evaluable mechanical ventilationdetailed results RAPID (Sholzberg), 2021 0.70 [0.32; 1.54]
0.70 [0.32 ; 1.54 ] RAPID (Sholzberg), 2021 1 0% 465 NA not evaluable viral clearance detailed results Ravichandran, 2021 1.71 [0.80; 3.64]
1.71 [0.80 ; 3.64 ] Ravichandran, 2021 1 0% 122 NA not evaluable viral clearance by day 7detailed results Ravichandran, 2021 1.71 [0.80; 3.64]
1.71 [0.80 ; 3.64 ] Ravichandran, 2021 1 0% 122 NA not evaluable ICU admissiondetailed results RAPID (Sholzberg), 2021 0.79 [0.48; 1.30]
0.79 [0.48 ; 1.30 ] RAPID (Sholzberg), 2021 1 0% 465 NA not evaluable Major thrombotic events or deathdetailed results COVID-PACT, 2022 0.56 [0.32; 0.98]
REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 1.04 [0.80; 1.36]
0.80 [0.44 ; 1.46 ] COVID-PACT, 2022, REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 2 73% 1,473 moderate not evaluable adverse eventsdetailed results Ravichandran, 2021 1.04 [0.02; 52.86]
1.04 [0.02 ; 52.86 ] Ravichandran, 2021 1 0% 210 NA not evaluable Major bleedingdetailed results ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021 1.80 [0.88; 3.67]
COALIZAO ACTION, 2021 2.50 [0.78; 8.06]
COVID-PACT, 2022 3.86 [0.44; 34.07]
INSPIRATION, 2021 1.83 [0.53; 6.34]
REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 1.48 [0.74; 2.98]
1.80 [1.18 ; 2.75 ] ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients), 2021, COALIZAO ACTION, 2021, COVID-PACT, 2022, INSPIRATION, 2021, REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients), 2021 5 0% 4,876 moderate serious Thromboembolic eventsdetailed results COALIZAO ACTION, 2021 0.73 [0.41; 1.29]
INSPIRATION, 2021 1.07 [0.76; 1.49]
0.95 [0.68 ; 1.34 ] COALIZAO ACTION, 2021, INSPIRATION, 2021 2 21% 1,176 moderate not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-06 06:27 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 95,94,90,91
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290
