Immunosuppressants drugs - for COVID-19 method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death or transfer to ICUno RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies
deaths 1.08 [0.77, 1.52]< 10%6 studies (6 / -)32.3 %highnot evaluable lowcrucial-
deaths (time to event analysis only)no RCT reported results for this endpoint, but 5 observational studies are available. Clear RCT filter to include observational studies
clinical improvement 1.17 [1.00, 1.38]> 10%5 studies (5 / -)97.6 %highserious lowimportant-
clinical improvement (28-day) 1.19 [0.81, 1.75]> 10%1 study (1 / -)81.0 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.15 [0.90, 1.47]> 10%1 study (1 / -)86.8 %lownot evaluable highimportant-
clinical worsening 0.78 [0.53, 1.14]< 136%4 studies (4 / -)90.2 %some concernnot evaluable moderateimportant-
death or ventilation 0.59 [0.43, 0.80]< 10%5 studies (5 / -)100.0 %highnot evaluable lowimportant-
hospital discharge 1.16 [0.90, 1.49]> 10%1 study (1 / -)87.9 %lownot evaluable highimportant-
ventilation 0.27 [0.14, 0.55]< 10%2 studies (2 / -)100.0 %highnot evaluable lowimportant-
ICU admissionno RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies
off oxygenation 1.46 [0.79, 2.68]> 128%2 studies (2 / -)88.7 %highnot evaluable lownon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 2 pathologies: 87,95,94,90,91,97 91, 90