baricitinib - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.68 [0.51, 0.91]< 165%4 studies (4/-)99.6 %some concernnot evaluable moderatecrucial-
deaths 0.68 [0.51, 0.91]< 165%4 studies (4/-)99.6 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.59 [0.45, 0.78]< 10%2 studies (2/-)100.0 %lownot evaluable highcrucial-
clinical deterioration 1.12 [0.58, 2.16]< 10%1 study (1/-)36.8 %lownot evaluable highimportant-
clinical improvement 1.24 [1.03, 1.48]> 146%3 studies (3/-)99.0 %lownot evaluable highimportant-
clinical improvement (14-day) 1.31 [1.13, 1.52]> 10%3 studies (3/-)100.0 %lownot evaluable highimportant-
clinical improvement (28-day) 1.82 [0.87, 3.81]> 10%1 study (1/-)94.4 %lownot evaluable highimportant-
clinical improvement (time to event analysis only) 1.16 [1.01, 1.33]> 10%1 study (1/-)98.5 %lownot evaluable highimportant-
death or ventilation 0.82 [0.65, 1.05]< 158%2 studies (2/-)93.9 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.78 [0.59, 1.04]< 155%2 studies (2/-)95.3 %some concernnot evaluable moderateimportant-
recovery 1.57 [0.77, 3.20]> 10%1 study (1/-)89.3 %lownot evaluable highnon important-

safety endpoints 00

superinfection 0.50 [0.32, 0.79]< 10%1 study (1/-)99.8 %lownot evaluable highimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.