Immunosuppressants drugs - versus control - for COVID-19 mild to moderate pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.77 [0.43, 1.40]< 10%2 studies (2/-)80.4 %some concernnot evaluable moderatecrucial-
deaths 0.79 [0.55, 1.13]< 10%5 studies (5/-)90.0 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.51 [0.35, 0.75]< 148%4 studies (4/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement 1.18 [0.94, 1.48]> 10%2 studies (2/-)92.5 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.15 [0.90, 1.47]> 10%1 study (1/-)86.8 %some concernnot evaluable moderateimportant-
death or ventilation 0.88 [0.54, 1.44]< 171%4 studies (4/-)69.5 %some concernnot evaluable moderateimportant-
hospital discharge 1.16 [0.90, 1.49]> 10%1 study (1/-)87.9 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.47 [0.03, 7.48]< 10%1 study (1/-)70.4 %lownot evaluable highimportant-

safety endpoints 00

serious adverse events 0.73 [0.45, 1.19]< 10%1 study (1/-)89.7 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.